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dc.contributor.authorMckay, Alannah KA
dc.contributor.authorPeeling, Peter
dc.contributor.authorPyne, David B
dc.contributor.authorWelvaert, Marijke
dc.contributor.authorTee, Nicolin
dc.contributor.authorLeckey, Jill J
dc.contributor.authorSharma, Avish P
dc.contributor.authorRoss, Megan LR
dc.contributor.authorGarvican-Lewis, Laura A
dc.contributor.authorSwinkels, Dorine W
dc.contributor.authorLaarakkers, Coby M
dc.contributor.authorBurke, Louise M
dc.date.accessioned2019-07-04T12:35:41Z
dc.date.available2019-07-04T12:35:41Z
dc.date.issued2019
dc.identifier.issn0195-9131
dc.identifier.doi10.1249/MSS.0000000000001816
dc.identifier.urihttp://hdl.handle.net/10072/384651
dc.description.abstractPURPOSE: The short-term restriction of carbohydrate (CHO) can potentially influence iron regulation via modification of postexercise interleukin-6 (IL-6) and hepcidin levels. This study examined the effect of a chronic ketogenic low-CHO high-fat (LCHF) diet on iron status and iron-regulatory markers in elite athletes. METHODS: International-level race walkers (n = 50) were allocated to one of three dietary interventions: (i) a high-CHO diet (n = 16), (ii) a periodized CHO availability (n = 17), or (iii) an LCHF diet (n = 17) while completing a periodized training program for 3 wk. A 19- to 25-km race walking test protocol was completed at baseline and after adaptation, and changes in serum ferritin, IL-6, and hepcidin concentrations were measured. Results from high-CHO and periodized CHO were combined into one group (CHO; n = 33) for analysis. RESULTS: The decrease in serum ferritin across the intervention period was substantially greater in the CHO group (37%) compared with the LCHF (23%) group (P = 0.021). After dietary intervention, the postexercise increase in IL-6 was greater in LCHF (13.6-fold increase; 95% confidence interval [CI] = 7.1-21.4) than athletes adhering to a CHO-rich diet (7.6-fold increase; 95% CI = 5.5-10.2; P = 0.033). Although no significant differences occurred between diets, CI values indicate that 3 h postexercise hepcidin concentrations were lower after dietary intervention compared with baseline in CHO (β = -4.3; 95% CI = -6.6 to -2.0), with no differences evident in LCHF. CONCLUSION: Athletes who adhered to a CHO-rich diet experienced favorable changes to the postexercise IL-6 and hepcidin response, relative to the LCHF group. Lower serum ferritin after 3 wk of additional dietary CHO might reflect a larger more adaptive hematological response to training.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.publisher.urihttps://insights.ovid.com/crossref?an=00005768-201903000-00020&clickthrough=y
dc.relation.ispartofpagefrom548
dc.relation.ispartofpageto555
dc.relation.ispartofissue3
dc.relation.ispartofjournalMEDICINE AND SCIENCE IN SPORTS AND EXERCISE
dc.relation.ispartofvolume51
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchHealth services and systems
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchcode4207
dc.subject.fieldofresearchcode3208
dc.subject.fieldofresearchcode4203
dc.subject.fieldofresearchcode4206
dc.titleChronic Adherence to a Ketogenic Diet Modifies Iron Metabolism in Elite Athletes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorSharma, Avish


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