Acrotrione: An Oxidized Xanthene from the Roots of Acronychia pubescens
Author(s)
Robertson, LP
Lucantoni, L
Duffy, S
Avery, VM
Carroll, AR
Griffith University Author(s)
Year published
2019
Metadata
Show full item recordAbstract
A new oxidized xanthene, acrotrione (1), and two known acetophenones (2 and 3) were isolated from a methanol extract of the roots of Acronychia pubescens. The structure of 1 was elucidated on the basis of its (+)-HRESIMS, 2D NMR, and ECD data. Acritrione (1) contains an unusual oxidized furo[2,3-c]xanthene moiety that has not been previously reported. Moderate antiplasmodial activity for these natural products against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum was determined with IC 50 values ranging from 1.7 to 4.7 μM.A new oxidized xanthene, acrotrione (1), and two known acetophenones (2 and 3) were isolated from a methanol extract of the roots of Acronychia pubescens. The structure of 1 was elucidated on the basis of its (+)-HRESIMS, 2D NMR, and ECD data. Acritrione (1) contains an unusual oxidized furo[2,3-c]xanthene moiety that has not been previously reported. Moderate antiplasmodial activity for these natural products against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum was determined with IC 50 values ranging from 1.7 to 4.7 μM.
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Journal Title
Journal of Natural Products
Volume
82
Subject
Biological Sciences
Medical and Health Sciences
Chemical Sciences