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  • Acrotrione: An Oxidized Xanthene from the Roots of Acronychia pubescens

    Author(s)
    Robertson, LP
    Lucantoni, L
    Duffy, S
    Avery, VM
    Carroll, AR
    Griffith University Author(s)
    Duffy, Sandra
    Avery, Vicky M.
    Carroll, Anthony R.
    Robertson, Luke P.
    Lucantoni, Leonardo
    Year published
    2019
    Metadata
    Show full item record
    Abstract
    A new oxidized xanthene, acrotrione (1), and two known acetophenones (2 and 3) were isolated from a methanol extract of the roots of Acronychia pubescens. The structure of 1 was elucidated on the basis of its (+)-HRESIMS, 2D NMR, and ECD data. Acritrione (1) contains an unusual oxidized furo[2,3-c]xanthene moiety that has not been previously reported. Moderate antiplasmodial activity for these natural products against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum was determined with IC 50 values ranging from 1.7 to 4.7 μM.A new oxidized xanthene, acrotrione (1), and two known acetophenones (2 and 3) were isolated from a methanol extract of the roots of Acronychia pubescens. The structure of 1 was elucidated on the basis of its (+)-HRESIMS, 2D NMR, and ECD data. Acritrione (1) contains an unusual oxidized furo[2,3-c]xanthene moiety that has not been previously reported. Moderate antiplasmodial activity for these natural products against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum was determined with IC 50 values ranging from 1.7 to 4.7 μM.
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    Journal Title
    Journal of Natural Products
    Volume
    82
    DOI
    https://doi.org/10.1021/acs.jnatprod.8b00956
    Subject
    Biological Sciences
    Medical and Health Sciences
    Chemical Sciences
    Publication URI
    http://hdl.handle.net/10072/384692
    Collection
    • Journal articles

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