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dc.contributor.authorMeinert, Christoph
dc.contributor.authorTheodoropoulos, Christina
dc.contributor.authorKlein, Travis J
dc.contributor.authorHutmacher, Dietmar W
dc.contributor.authorLoessner, Daniela
dc.contributor.editorCulig, Z
dc.date.accessioned2019-07-03T12:36:43Z
dc.date.available2019-07-03T12:36:43Z
dc.date.issued2018
dc.identifier.isbn978-1-4939-7843-4
dc.identifier.issn1064-3745
dc.identifier.doi10.1007/978-1-4939-7845-8_10
dc.identifier.urihttp://hdl.handle.net/10072/384716
dc.description.abstractModern tissue engineering technologies have delivered tools to recreate a cell’s naturally occurring niche in vitro and to investigate normal and pathological cell–cell and cell–niche interactions. Hydrogel biomaterials mimic crucial properties of native extracellular matrices, including mechanical support, cell adhesion sites and proteolytic degradability. As such, they are applied as 3D cell culture platforms to replicate tissue-like architectures observed in vivo, allowing physiologically relevant cell behaviors. Here we review bioengineered 3D approaches used for prostate and breast cancer. Furthermore, we describe the synthesis and use of gelatin methacryloyl-based hydrogels as in vitro 3D cancer model. This platform is used to engineer the microenvironments for prostate and breast cancer cells to study processes regulating spheroid formation, cell functions and responses to therapeutic compounds. Collectively, these bioengineered 3D approaches provide cell biologists with innovative pre-clinical tools that integrate the complexity of the disease seen in patients to advance our knowledge of cancer cell physiology and the contribution of a tumor’s surrounding milieu.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherHUMANA PRESS INC
dc.relation.ispartofbooktitlePROSTATE CANCER: METHODS AND PROTOCOLS
dc.relation.ispartofpagefrom175
dc.relation.ispartofpageto194
dc.relation.ispartofjournalPROSTATE CANCER: METHODS AND PROTOCOLS
dc.relation.ispartofvolume1786
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchOther Chemical Sciences
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode0399
dc.titleA Method for Prostate and Breast Cancer Cell Spheroid Cultures Using Gelatin Methacryloyl-Based Hydrogels
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorHutmacher, Dietmar W.


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