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dc.contributor.authorNguyen, Huynhen_US
dc.contributor.authorA.F. Morgan, Daviden_US
dc.contributor.authorForwood, Marken_US
dc.contributor.editorRH Rothmanen_US
dc.date.accessioned2017-04-24T09:05:01Z
dc.date.available2017-04-24T09:05:01Z
dc.date.issued2011en_US
dc.date.modified2013-05-29T03:07:18Z
dc.identifier.issn08835403en_US
dc.identifier.doi10.1016/j.arth.2010.03.032en_US
dc.identifier.urihttp://hdl.handle.net/10072/38482
dc.description.abstractA radiation sterilization dose (RSD) of 25 kGy is deleterious to bone allografts. This study aimed to establish a lower RSD for bone allografts using method 1 of International Standard Organisation 11137.2:2006. This provides a database to select an RSD corresponding to an allograft's bioburden, given that the bioburden's gamma resistance is equal to or less than the standard. This can be verified by irradiating 100 allografts at a dose selected to provide a sterility assurance level of 10-2. The bioburden of our allografts was 0, which prescribed a verification dose of 1.3 kGy. After irradiating 100 llografts, sterility tests returned no positive cultures. We therefore validated an RSD of 11 kGy for allografts with that bioburden. According to the standard, this RSD provides a sterility assurance level of 10-6 for bone allografts.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent179060 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom303en_US
dc.relation.ispartofpageto308en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalJournal of Arthroplastyen_US
dc.relation.ispartofvolume26en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchOrthopaedicsen_US
dc.subject.fieldofresearchcode110314en_US
dc.titleValidation of 11 kGy as a Radiation Sterilisation Dose for Frozen Bone Allograftsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.rights.copyrightCopyright 2010 Elsevier Inc. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_US
gro.date.issued2011
gro.hasfulltextFull Text


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