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  • The effect of including increased arterial stiffness in the upper body when modelling Coarctation of the Aorta

    Author(s)
    Pathirana, Dilan
    Johnston, Barbara
    Johnston, Peter
    Griffith University Author(s)
    Pathirana, Dilan
    Johnston, Barbara M.
    Johnston, Peter R.
    Year published
    2019
    Metadata
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    Abstract
    Coarctation of the Aorta is a congenital narrowing of the aorta and diagnosis can be difficult. Treatments result in idiopathic sequelae including hypertension. Untreated patients are known to develop increased arterial stiffness in the upper body, which worsens with time. We present results from simulations with a one-dimensional mathematical model, about the effect of stiffness, stenting, surgery and coarctation severity on blood pressure, Pulsatility and Resistivity Index. One conclusion is that increased stiffness may explain both hypertension in treated patients and why diagnosis can be difficult.Coarctation of the Aorta is a congenital narrowing of the aorta and diagnosis can be difficult. Treatments result in idiopathic sequelae including hypertension. Untreated patients are known to develop increased arterial stiffness in the upper body, which worsens with time. We present results from simulations with a one-dimensional mathematical model, about the effect of stiffness, stenting, surgery and coarctation severity on blood pressure, Pulsatility and Resistivity Index. One conclusion is that increased stiffness may explain both hypertension in treated patients and why diagnosis can be difficult.
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    Journal Title
    COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
    Volume
    22
    Issue
    5
    DOI
    https://doi.org/10.1080/10255842.2018.1564821
    Subject
    Biomedical Engineering
    Dentistry
    Publication URI
    http://hdl.handle.net/10072/384887
    Collection
    • Journal articles

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