Show simple item record

dc.contributor.authorChakradeo, Katrina
dc.contributor.authorChia, YY Paul
dc.contributor.authorLiu, Cheng
dc.contributor.authorMudge, David W
dc.contributor.authorDe Silva, Janath
dc.date.accessioned2019-06-08T01:32:17Z
dc.date.available2019-06-08T01:32:17Z
dc.date.issued2018
dc.identifier.issn1471-2369
dc.identifier.doi10.1186/s12882-018-0815-7
dc.identifier.urihttp://hdl.handle.net/10072/384905
dc.description.abstractBackground: Cellulitis is an unusual presentation of disseminated cryptococcosis, a serious infection seen predominantly in immunocompromised hosts. Disseminated cryptococcosis carries significant morbidity for transplant recipients, especially of the pulmonary and central nervous systems, and carries a high mortality risk. Case presentation: We report a 59-year-old renal transplant recipient who presented with bilateral lower leg cellulitis without other symptoms or signs. Failure of conventional therapy for cellulitis prompted a skin biopsy confirming cryptococcal cellulitis. Additional evaluation to exclude disseminated disease revealed Cryptococcus neoformans in blood cultures and cerebrospinal fluid (CSF). Treatment included reduction in immunosuppression regimen and targeted treatment for cryptococcal disease with liposomal amphotericin B and flucytosine followed by fluconazole consolidation and maintenance therapy. Treatment with liposomal amphotericin B and flucytosine followed by fluconazole consolidation and maintenance therapy achieved a good clinical response. Our patient achieved significant reduction in leg cellulitis and recovered without serious complication. Conclusions: This case suggests that cutaneous cryptococcosis in immunosuppressed patients warrants a low threshold for investigation for disseminated disease even in the absence of other symptoms or signs.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBMC
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto6
dc.relation.ispartofissue18
dc.relation.ispartofjournalBMC NEPHROLOGY
dc.relation.ispartofvolume19
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3202
dc.titleDisseminated cryptococcosis presenting initially as lower limb cellulitis in a renal transplant recipient - a case report
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
gro.hasfulltextFull Text
gro.griffith.authorChakradeo, Katrina K.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record