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dc.contributor.authorCotrim, Camila A
dc.contributor.authorJarrott, Russell J
dc.contributor.authorMartin, Jennifer L
dc.contributor.authorDrew, David
dc.date.accessioned2019-06-19T13:09:16Z
dc.date.available2019-06-19T13:09:16Z
dc.date.issued2019
dc.identifier.issn2059-7983
dc.identifier.doi10.1107/S2059798319003814
dc.identifier.urihttp://hdl.handle.net/10072/385093
dc.description.abstractThe cation diffusion facilitators (CDFs) are a family of membrane-bound proteins that maintain cellular homeostasis of essential metal ions. In humans, the zinc-transporter CDF family members (ZnTs) play important roles in zinc homeostasis. They do this by facilitating zinc efflux from the cytoplasm to the extracellular space across the plasma membrane or into intracellular organelles. Several ZnTs have been implicated in human health owing to their association with type 2 diabetes and neurodegenerative diseases. Although the structure determination of CDF family members is not trivial, recent advances in membrane-protein structural biology have resulted in two structures of bacterial YiiPs and several structures of their soluble C-terminal domains. These data reveal new insights into the molecular mechanism of ZnT proteins, suggesting a unique rocking-bundle mechanism that provides alternating access to the metal-binding site.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherINT UNION CRYSTALLOGRAPHY
dc.relation.ispartofpagefrom357
dc.relation.ispartofpageto367
dc.relation.ispartofjournalACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
dc.relation.ispartofvolume75
dc.subject.fieldofresearchPhysical sciences
dc.subject.fieldofresearchcode51
dc.titleA structural overview of the zinc transporters in the cation diffusion facilitator family
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2019. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0)) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
gro.hasfulltextFull Text
gro.griffith.authorMartin, Jennifer


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