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dc.contributor.authorLi, Z
dc.contributor.authorYan, C
dc.contributor.authorLv, QY
dc.contributor.authorYi, ZH
dc.contributor.authorZhang, JY
dc.contributor.authorWang, JH
dc.contributor.authorLui, SSY
dc.contributor.authorXu, YF
dc.contributor.authorCheung, EFC
dc.contributor.authorGur, RE
dc.contributor.authorGur, RC
dc.contributor.authorChan, RCK
dc.date.accessioned2019-06-18T12:31:47Z
dc.date.available2019-06-18T12:31:47Z
dc.date.issued2018
dc.identifier.issn0920-9964
dc.identifier.doi10.1016/j.schres.2017.08.043
dc.identifier.urihttp://hdl.handle.net/10072/385163
dc.description.abstractDespite empirical findings showing that patients with schizophrenia and their unaffected first-degree relatives have deficits in processing monetary incentives, it is unclear whether similar deficits could be demonstrated for affective incentives. Twenty-six patients with schizophrenia and 26 age and gender matched healthy controls; 23 unaffected first-degree relatives and 23 matched healthy controls were recruited to complete a Monetary Incentive Delay (MID) task and an Affective Incentive Delay (AID) task in a 3-Tesla MRI scanner. Hypoactivation in the dorsal striatum when anticipating monetary incentives were found in patients with schizophrenia and their unaffected first-degree relatives compared with healthy controls. Furthermore, patients with schizophrenia showed hyperactivation in the ventral striatum when receiving both monetary and affective incentives. These findings suggest that disorganized striatal function, regardless of incentive types, may be present in patients with schizophrenia and before the onset of illness in their first-degree unaffected relatives.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofpagefrom215
dc.relation.ispartofpageto221
dc.relation.ispartofjournalSchizophrenia Research
dc.relation.ispartofvolume195
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchPsychology and Cognitive Sciences
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode17
dc.titleStriatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorChan, Raymond


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