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dc.contributor.authorWang, Y
dc.contributor.authorEttinger, U
dc.contributor.authorMeindl, T
dc.contributor.authorChan, RCK
dc.date.accessioned2019-06-18T12:31:46Z
dc.date.available2019-06-18T12:31:46Z
dc.date.issued2018
dc.identifier.issn1065-9471
dc.identifier.doi10.1002/hbm.23842
dc.identifier.urihttp://hdl.handle.net/10072/385203
dc.description.abstractAltered striatocortical functional connectivity has been suggested to be a trait marker of schizophrenia spectrum disorders, including schizotypal personality. In the present study, we examined the association between schizotypal personality traits and striatocortical functional connectivity in a sample of healthy adults. The German version of the Schizotypal Personality Questionnaire was obtained from N = 111 participants recruited from the general public. Resting-state functional magnetic resonance imaging scans were acquired at 3T. Six striatal seed regions in each hemisphere were defined and striatocortical resting-state functional connectivity (rsFC) as well as its lateralization indices was calculated. Regression analysis showed that schizotypy scores, especially from the positive dimension, were positively correlated with rsFC between ventral striatum and frontal cortex and negatively associated with rsFC between dorsal striatum and posterior cingulate. No significant associations were found between negative dimension schizotypy and striatocortical rsFC. We also found positive correlations between schizotypy total scores and lateralization index of right dorsal caudate and right rostral putamen. In conclusion, the present study extends previous evidence of altered striatocortical rsFC in the schizophrenia spectrum. The observed associations resemble in part the alterations observed in psychotic patients and their relatives, providing support for dimensionality from schizotypal personality to the clinical disorder. Hum Brain Mapp 39:288–299, 2018. © 2017 Wiley Periodicals, Inc.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofpagefrom288
dc.relation.ispartofpageto299
dc.relation.ispartofissue1
dc.relation.ispartofjournalHuman Brain Mapping
dc.relation.ispartofvolume39
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1702
dc.titleAssociation of schizotypy with striatocortical functional connectivity and its asymmetry in healthy adults
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorChan, Raymond


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