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dc.contributor.authorZou, LQ
dc.contributor.authorZhou, HY
dc.contributor.authorZhuang, Y
dc.contributor.authorvan Hartevelt, TJ
dc.contributor.authorLui, SSY
dc.contributor.authorCheung, EFC
dc.contributor.authorMøller, A
dc.contributor.authorKringelbach, ML
dc.contributor.authorChan, RCK
dc.date.accessioned2019-06-18T12:31:42Z
dc.date.available2019-06-18T12:31:42Z
dc.date.issued2018
dc.identifier.issn0028-3932
dc.identifier.doi10.1016/j.neuropsychologia.2018.02.003
dc.identifier.urihttp://hdl.handle.net/10072/385214
dc.description.abstractPleasure experience is an important part of normal healthy life and is essential for general and mental well-being. Many neuroimaging studies have investigated the underlying neural processing of verbal and visual modalities of reward. However, how the brain processes rewards in the olfactory modality is not fully understood. This study aimed to examine the neural basis of olfactory rewards in 25 healthy participants using functional magnetic resonance imaging (fMRI). We developed an Olfactory Incentive Delay (OLID) imaging task distinguishing between the anticipation and receipt of olfactory rewards and punishments. We found that the pallidum was activated during the anticipation of both olfactory rewards and punishments. The bilateral insula was activated independently from the odours’ hedonic valence during the receipt phase. In addition, right caudate activation during the anticipation of unpleasant odours was correlated with self-reported anticipatory hedonic traits, whereas bilateral insular activation during the receipt of pleasant odours was correlated with self-reported consummatory hedonic traits. These findings suggest that activity in the insula and the caudate may be biomarkers of anhedonia. These findings also highlight a useful and valid paradigm to study the neural circuitry underlying reward processing in people with anhedonia.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofpagefrom172
dc.relation.ispartofpageto179
dc.relation.ispartofjournalNeuropsychologia
dc.relation.ispartofvolume111
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1701
dc.subject.fieldofresearchcode1702
dc.titleNeural responses during the anticipation and receipt of olfactory reward and punishment in human
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorChan, Raymond


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