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dc.contributor.authorWang, YM
dc.contributor.authorZou, LQ
dc.contributor.authorXie, WL
dc.contributor.authorYang, ZY
dc.contributor.authorZhu, XZ
dc.contributor.authorCheung, EFC
dc.contributor.authorSørensen, TA
dc.contributor.authorMøller, A
dc.contributor.authorChan, RCK
dc.date.accessioned2019-06-18T12:31:39Z
dc.date.available2019-06-18T12:31:39Z
dc.date.issued2018
dc.identifier.issn0925-4927
dc.identifier.doi10.1016/j.pscychresns.2018.03.009
dc.identifier.urihttp://hdl.handle.net/10072/385218
dc.description.abstractRecent findings suggest that schizo-obsessive comorbidity (SOC) may be a unique diagnostic entity. We examined grey matter (GM) volume and cortical thickness in 22 patients with SOC, and compared them with 21 schizophrenia (SCZ) patients, 22 obsessive-compulsive disorder (OCD) patients and 22 healthy controls (HCs). We found that patients with SOC exhibited reduced GM volume in the left thalamus, the left inferior semi-lunar lobule of the cerebellum, the bilateral medial orbitofrontal cortex (medial oFC), the medial superior frontal gyrus (medial sFG), the rectus gyrus and the anterior cingulate cortex (aCC) compared with HCs. Patients with SOC also exhibited reduced cortical thickness in the right superior temporal gyrus (sTG), the right angular gyrus, the right supplementary motor area (SMA), the right middle cingulate cortex (mCC) and the right middle occipital gyrus (mOG) compared with HCs. Together with the differences in GM volume and cortical thickness between patients with SOC and patients with only SCZ or only OCD, these findings highlight the GM changes specific to patients with SOC.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofpagefrom65
dc.relation.ispartofpageto72
dc.relation.ispartofjournalPsychiatry Research - Neuroimaging
dc.relation.ispartofvolume276
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode5204
dc.titleAltered grey matter volume and cortical thickness in patients with schizo-obsessive comorbidity
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorChan, Raymond


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