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  • Structural alterations in the caudate nucleus and precuneus in un-medicated anorexia nervosa patients

    Author(s)
    Yue, L
    Wang, Y
    Kaye, WH
    Kang, Q
    Huang, JB
    Cheung, EFC
    Xiao, SF
    Wang, Z
    Chen, J
    Chan, RCK
    Griffith University Author(s)
    Chan, Raymond
    Year published
    2018
    Metadata
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    Abstract
    Anorexia nervosa (AN) is a mental disorder characterized by a preoccupation with thinness and may be associated with brain structural alteration. The aim of the study was to examine the brain structural alteration in AN patients, including subcortical structure volume and cortical thickness. Thirty-five un-medicated AN patients and 20 matched healthy controls underwent structural magnetic resonance imaging brain scans. High resolution structural images were acquired on a SIEMENS 3T scanner and preprocessed using FreeSurfer software. Subcortical structure volume and cortical thickness were compared between the two groups. We ...
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    Anorexia nervosa (AN) is a mental disorder characterized by a preoccupation with thinness and may be associated with brain structural alteration. The aim of the study was to examine the brain structural alteration in AN patients, including subcortical structure volume and cortical thickness. Thirty-five un-medicated AN patients and 20 matched healthy controls underwent structural magnetic resonance imaging brain scans. High resolution structural images were acquired on a SIEMENS 3T scanner and preprocessed using FreeSurfer software. Subcortical structure volume and cortical thickness were compared between the two groups. We found larger percentage of caudate volume relative to total grey matter (GM) volume in the AN group. Reduced cortical thickness at the left precuneus was also observed in AN patients. Moreover, an interaction between group and hemisphere was found, suggesting that cortical thinning was more prominent in the left hemisphere in AN patients. These findings provide further evidence for structural brain abnormalities in patients with AN.
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    Journal Title
    Psychiatry Research - Neuroimaging
    Volume
    281
    DOI
    https://doi.org/10.1016/j.pscychresns.2018.08.009
    Subject
    Clinical sciences
    Neurosciences
    Cognitive and computational psychology
    Publication URI
    http://hdl.handle.net/10072/385226
    Collection
    • Journal articles

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