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dc.contributor.authorAlsharifi, Mohammed
dc.contributor.authorLobigs, Mario
dc.contributor.authorBettadapura, Jayaram
dc.contributor.authorKoskinen, Aulikki
dc.contributor.authorMüllbacher, Arno
dc.contributor.editorDr. Natalie Wilder
dc.date.accessioned2017-05-03T16:00:59Z
dc.date.available2017-05-03T16:00:59Z
dc.date.issued2008
dc.date.modified2011-05-03T04:46:46Z
dc.identifier.issn00221317
dc.identifier.doi10.1099/vir.0.83626-0
dc.identifier.urihttp://hdl.handle.net/10072/38526
dc.description.abstractPreviously, we have shown that mice defective in granule exocytosis and/or Fas.L/Fas-mediated cytolytic pathways are significantly more resistant to alphavirus, Semliki Forest virus (SFV), infection compared with wild-type mice. Here, we evaluated SFV replication in different tissues of mice defective in both cytolytic pathways (perf-/-xgld) relative to that in wild-type counterparts and found that viral replication in perf-/-xgld mice is remarkably restricted. Although the mechanism responsible for this observation is yet to be established, the lower virus titres found in these mice indicate that the role of cytolytic effector molecules in antiviral immunity needs to be re-evaluated.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSociety for General Microbiologists
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1942
dc.relation.ispartofpageto1944
dc.relation.ispartofjournalJournal of General Virology
dc.relation.ispartofvolume89
dc.rights.retentionY
dc.subject.fieldofresearchMedical Virology
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchAgricultural and Veterinary Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode110804
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode07
dc.subject.fieldofresearchcode11
dc.titleRestricted Semliki Forest virus replication in Perforin and Fas-ligand double deficient mice
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorBettadapura, Jayaram


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