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dc.contributor.authorHoughton, David
dc.contributor.authorZalewski, Pawel
dc.contributor.authorHallsworth, Kate
dc.contributor.authorCassidy, Sophie
dc.contributor.authorThoma, Christian
dc.contributor.authorAvery, Leah
dc.contributor.authorSlomko, Joanna
dc.contributor.authorHardy, Timothy
dc.contributor.authorBurt, Alastair D
dc.contributor.authorTiniakos, Dina
dc.contributor.authorHollingsworth, Kieren G
dc.contributor.authorTaylor, Roy
dc.contributor.authorDay, Christopher P
dc.contributor.authorMasson, Steven
dc.contributor.authorMcPherson, Stuart
dc.contributor.authorAnstee, Quentin M
dc.contributor.authorNewton, Julia L
dc.contributor.authorTrenell, Michael
dc.date.accessioned2019-06-19T13:05:15Z
dc.date.available2019-06-19T13:05:15Z
dc.date.issued2019
dc.identifier.issn0168-8278
dc.identifier.doi10.1016/j.jhep.2019.01.035
dc.identifier.urihttp://hdl.handle.net/10072/385305
dc.description.abstractBackground & Aims: Cardiovascular disease is the principle cause of death in patients with elevated liver fat unrelated to alcohol consumption, more so than liver-related morbidity and mortality. The aim of this study was to evaluate the relationship between liver fat and cardiac and autonomic function, as well as to assess how impairment in cardiac and autonomic function is influenced by metabolic risk factors. Methods: Cardiovascular and autonomic function were assessed in 96 sedentary individuals: i) non-alcoholic fatty liver disease (NAFLD) (n = 46, hepatic steatosis >5% by magnetic resonance spectroscopy), ii) Hepatic steatosis and alcohol (dual aetiology fatty liver disease [DAFLD]) (n = 16, hepatic steatosis >5%, consuming >20 g/day of alcohol) and iii) CONTROL (n = 34, no cardiac, liver or metabolic disorders, <20 g/day of alcohol). Results: Patients with NAFLD and DAFLD had significantly impaired cardiac and autonomic function when compared with controls. Diastolic variability and systolic variability (LF/HF-sBP [n/1]; 2.3 (1.7) and 2.3 (1.5) vs. 3.4 (1.5), p <0.01) were impaired in patients with NAFLD and DAFLD when compared to controls, with DAFLD individuals showing a decrease in diastolic variability relative to NAFLD patients. Hepatic steatosis and fasting glucose were negatively correlated with stroke volume index. Fibrosis stage was significantly negatively associated with mean blood pressure (r = −0.47, p = 0.02), diastolic variability (r = −0.58, p ≤0.01) and systolic variability (r = −0.42, p = 0.04). Hepatic steatosis was independently associated with cardiac function (p ≤0.01); TNF-α (p ≤0.05) and CK-18 (p ≤0.05) were independently associated with autonomic function. Conclusion: Cardiac and autonomic impairments appear to be dependent on level of liver fat, metabolic dysfunction, inflammation and fibrosis staging, and to a lesser extent alcohol intake. Interventions should be sought to moderate the excess cardiovascular risk in patients with NAFLD or DAFLD.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier Science
dc.relation.ispartofpagefrom1203
dc.relation.ispartofpageto1213
dc.relation.ispartofissue6
dc.relation.ispartofjournalJOURNAL OF HEPATOLOGY
dc.relation.ispartofvolume70
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1117
dc.titleThe degree of hepatic steatosis associates with impaired cardiac and autonomic function
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2019 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorSlomko, Joanna


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