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dc.contributor.authorLee, Sung Ryul
dc.contributor.authorNilius, Bernd
dc.contributor.authorHan, Jin
dc.contributor.editorNilius, B
dc.contributor.editorDeTombe, P
dc.contributor.editorGudermann, T
dc.contributor.editorJahn, R
dc.contributor.editorLill, R
dc.contributor.editorPetersen, OH
dc.date.accessioned2019-07-11T12:30:52Z
dc.date.available2019-07-11T12:30:52Z
dc.date.issued2018
dc.identifier.isbn978-3-319-78773-2
dc.identifier.issn0303-4240
dc.identifier.doi10.1007/112_2017_7
dc.identifier.urihttp://hdl.handle.net/10072/385311
dc.description.abstractCarbon monoxide (CO), hydrogen sulfide (H2S), and nitric oxide (NO) constitute endogenous gaseous molecules produced by specific enzymes. These gases are chemically simple, but exert multiple effects and act through shared molecular targets to control both physiology and pathophysiology in the cardiovascular system (CVS). The gases act via direct and/or indirect interactions with each other in proteins such as heme-containing enzymes, the mitochondrial respiratory complex, and ion channels, among others. Studies of the major impacts of CO, H2S, and NO on the CVS have revealed their involvement in controlling blood pressure and in reducing cardiac reperfusion injuries, although their functional roles are not limited to these conditions. In this review, the basic aspects of CO, H2S, and NO, including their production and effects on enzymes, mitochondrial respiration and biogenesis, and ion channels are briefly addressed to provide insight into their biology with respect to the CVS. Finally, potential therapeutic applications of CO, H2S, and NO with the CVS are addressed, based on the use of exogenous donors and different types of delivery systems.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSPRINGER-VERLAG BERLIN
dc.relation.ispartofbooktitleREVIEWS OF PHYSIOLOGY, BIOCHEMISTRY AND PHARMACOLOGY, VOL. 174
dc.relation.ispartofpagefrom81
dc.relation.ispartofpageto156
dc.relation.ispartofjournalREVIEWS OF PHYSIOLOGY, BIOCHEMISTRY AND PHARMACOLOGY, VOL. 174
dc.relation.ispartofvolume174
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchMedical Biochemistry and Metabolomics
dc.subject.fieldofresearchMedical Physiology
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1101
dc.subject.fieldofresearchcode1116
dc.titleGaseous Signaling Molecules in Cardiovascular Function: From Mechanisms to Clinical Translation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorNilius, Bernd


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