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dc.contributor.authorFujita, Yoshioen_US
dc.contributor.authorM. Abdel-Aal, Abu-Bakeren_US
dc.contributor.authorWimmer, Norberten_US
dc.contributor.authorR. Batzloff, Michaelen_US
dc.contributor.authorF. Good, Michaelen_US
dc.contributor.authorToth, Istvanen_US
dc.date.accessioned2017-04-24T09:58:26Z
dc.date.available2017-04-24T09:58:26Z
dc.date.issued2008en_US
dc.date.modified2014-01-08T05:06:41Z
dc.identifier.issn09680896en_US
dc.identifier.doi10.1016/j.bmc.2008.08.064en_US
dc.identifier.urihttp://hdl.handle.net/10072/38544
dc.description.abstractSynthesis of four glycolipids with different number of lauroyl groups on glucose or cellobiose as scaffolds is described. Their immunological evaluations either admixed with or covalently linked to J8, a peptide antigen derived from the C-terminus of the antiphagocytic M-protein of group A streptococcus, are also investigated. Administration of mixtures of J8 and glycolipids to B10BR (H-2k) mice induced low-levels of J8-specific IgG antibodies. While glycolipopeptides, in which J8 was covalently linked to the synthetic glycolipids, demonstrated high-levels of antibody titers comparable with the co-administration of these glycolipopeptides with complete Freund's adjuvant, suggesting clearly the strong potency of the synthesized glycolipids as self-adjuvanting moieties.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherElsevier Scienceen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom8907en_US
dc.relation.ispartofpageto8913en_US
dc.relation.ispartofissue19en_US
dc.relation.ispartofjournalBioorganic & medicinal chemistry.en_US
dc.relation.ispartofvolume16en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchInfectious Agentsen_US
dc.subject.fieldofresearchcode060502en_US
dc.titleSynthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidatesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2008
gro.hasfulltextNo Full Text


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