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dc.contributor.authorFujita, Yoshio
dc.contributor.authorAbdel-Aal, Abu-Baker M.
dc.contributor.authorWimmer, Norbert
dc.contributor.authorBatzloff, Michael R.
dc.contributor.authorGood, Michael F.
dc.contributor.authorToth, Istvan
dc.date.accessioned2017-05-03T12:54:00Z
dc.date.available2017-05-03T12:54:00Z
dc.date.issued2008
dc.date.modified2014-01-08T05:06:41Z
dc.identifier.issn09680896
dc.identifier.doi10.1016/j.bmc.2008.08.064
dc.identifier.urihttp://hdl.handle.net/10072/38544
dc.description.abstractSynthesis of four glycolipids with different number of lauroyl groups on glucose or cellobiose as scaffolds is described. Their immunological evaluations either admixed with or covalently linked to J8, a peptide antigen derived from the C-terminus of the antiphagocytic M-protein of group A streptococcus, are also investigated. Administration of mixtures of J8 and glycolipids to B10BR (H-2k) mice induced low-levels of J8-specific IgG antibodies. While glycolipopeptides, in which J8 was covalently linked to the synthetic glycolipids, demonstrated high-levels of antibody titers comparable with the co-administration of these glycolipopeptides with complete Freund's adjuvant, suggesting clearly the strong potency of the synthesized glycolipids as self-adjuvanting moieties.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier Science
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom8907
dc.relation.ispartofpageto8913
dc.relation.ispartofissue19
dc.relation.ispartofjournalBioorganic & medicinal chemistry.
dc.relation.ispartofvolume16
dc.rights.retentionY
dc.subject.fieldofresearchInfectious Agents
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchOrganic Chemistry
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode060502
dc.subject.fieldofresearchcode0304
dc.subject.fieldofresearchcode0305
dc.subject.fieldofresearchcode1115
dc.titleSynthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidates
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorBatzloff, Michael R.


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