dc.contributor.author | Fujita, Yoshio | |
dc.contributor.author | Abdel-Aal, Abu-Baker M. | |
dc.contributor.author | Wimmer, Norbert | |
dc.contributor.author | Batzloff, Michael R. | |
dc.contributor.author | Good, Michael F. | |
dc.contributor.author | Toth, Istvan | |
dc.date.accessioned | 2017-05-03T12:54:00Z | |
dc.date.available | 2017-05-03T12:54:00Z | |
dc.date.issued | 2008 | |
dc.date.modified | 2014-01-08T05:06:41Z | |
dc.identifier.issn | 09680896 | |
dc.identifier.doi | 10.1016/j.bmc.2008.08.064 | |
dc.identifier.uri | http://hdl.handle.net/10072/38544 | |
dc.description.abstract | Synthesis of four glycolipids with different number of lauroyl groups on glucose or cellobiose as scaffolds is described. Their immunological evaluations either admixed with or covalently linked to J8, a peptide antigen derived from the C-terminus of the antiphagocytic M-protein of group A streptococcus, are also investigated. Administration of mixtures of J8 and glycolipids to B10BR (H-2k) mice induced low-levels of J8-specific IgG antibodies. While glycolipopeptides, in which J8 was covalently linked to the synthetic glycolipids, demonstrated high-levels of antibody titers comparable with the co-administration of these glycolipopeptides with complete Freund's adjuvant, suggesting clearly the strong potency of the synthesized glycolipids as self-adjuvanting moieties. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier Science | |
dc.publisher.place | United Kingdom | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 8907 | |
dc.relation.ispartofpageto | 8913 | |
dc.relation.ispartofissue | 19 | |
dc.relation.ispartofjournal | Bioorganic & medicinal chemistry. | |
dc.relation.ispartofvolume | 16 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Infectious Agents | |
dc.subject.fieldofresearch | Medicinal and Biomolecular Chemistry | |
dc.subject.fieldofresearch | Organic Chemistry | |
dc.subject.fieldofresearch | Pharmacology and Pharmaceutical Sciences | |
dc.subject.fieldofresearchcode | 060502 | |
dc.subject.fieldofresearchcode | 0304 | |
dc.subject.fieldofresearchcode | 0305 | |
dc.subject.fieldofresearchcode | 1115 | |
dc.title | Synthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidates | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2008 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Batzloff, Michael R. | |