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dc.contributor.authorGedmintas, Audraen_US
dc.contributor.authorCrilly, Juliaen_US
dc.contributor.authorRichards, Brenten_US
dc.contributor.authorComadira, Gregoryen_US
dc.contributor.authorCreamer, Julieen_US
dc.contributor.authorLind, Jamesen_US
dc.contributor.authorFoster, Michelleen_US
dc.date.accessioned2017-05-11T12:30:34Z
dc.date.available2017-05-11T12:30:34Z
dc.date.issued2010en_US
dc.date.modified2011-05-03T04:47:56Z
dc.identifier.issn14412772en_US
dc.identifier.urihttp://hdl.handle.net/10072/38560
dc.description.abstractBACKGROUND: Extended daily diafiltration (EDDf) is a prolonged intermittent dialysis technique introduced as an alternative to continuous renal replacement therapy in critically ill patients. Although EDDf has the advantages of ease of use, low cost and patient tolerability, there is concern that the high blood and dialysate flow rates used with EDDf may precipitate haemodynamic instability. OBJECTIVE: To identify whether haemodynamic changes occur during the course of EDDf therapy in adult patients who are admitted to the intensive care unit with sepsis and require dialysis. DESIGN, SETTING AND PARTICIPANTS: A prospective observational study of patients fitting the inclusion criteria who were admitted to the ICU of the Gold Coast Hospital, Queensland, during the period 1 January 2002 to 31 December 2005. MAIN OUTCOME MEASURES: Mean arterial pressure (MAP) and heart rate (HR) before, during and after EDDf treatment. RESULTS: 178 EDDf treatments were administered to 44 patients. Haemodynamic parameters remained stable during EDDf, despite median blood flow rates of 265 mL/min and dialysate flow rates of 300 mL/min: MAP was 81.2 mmHg before EDDf v 82.7 mmHg after EDDf (P = 0.13); HR was 100.4 beats/min before EDDf v 98.9 beats/ min after EDDf (P = 0.23). For treatments in which vasopressive support was required (n = 75), no increase in dose requirement was observed. Patient mortality at the time of hospital discharge (41%) was less than the rate predicted by APACHE III scores (52%). CONCLUSION: EDDf did not significantly worsen haemodynamic stability in patients with sepsis during their treatment.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherAustralasian Academy of Critical Care Medicineen_US
dc.publisher.placeAustraliaen_US
dc.publisher.urihttp://www.cicm.org.au/journal_load.php?year=2010&month=Septemberen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom203en_US
dc.relation.ispartofpageto208en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalCritical Care and Resuscitationen_US
dc.relation.ispartofvolume12en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchClinical Nursing: Secondary (Acute Care)en_US
dc.subject.fieldofresearchcode111003en_US
dc.titleHaemodynamic stability is maintained during extended daily diafiltration in critically ill septic patientsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2010
gro.hasfulltextNo Full Text


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