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  • Negative Schizotypy and Altered Functional Connectivity during Facial Emotion Processing

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    Accepted Manuscript (AM)
    Author(s)
    Wang, Y
    Li, Z
    Liu, WH
    Wei, XH
    Jiang, XQ
    Lui, SSY
    Ho-Wai So, S
    Cheung, EFC
    Debbane, M
    Chan, RCK
    Griffith University Author(s)
    Chan, Raymond
    Year published
    2018
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    Abstract
    Background: Impairment in facial emotion perception is an important domain of social cognition deficits in schizophrenia. Although impaired facial emotion perception has been found in individuals with negative schizotypy (NS), little is known about the corresponding change in brain functional connectivity. Methods: Sixty-four participants were classified into a high NS group (n = 34) and a low NS group (n = 30) based on their total scores on the Chapman scales for physical and social anhedonia. All participants undertook a facial emotion discrimination functional imaging task that consisted of four emotional valences ...
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    Background: Impairment in facial emotion perception is an important domain of social cognition deficits in schizophrenia. Although impaired facial emotion perception has been found in individuals with negative schizotypy (NS), little is known about the corresponding change in brain functional connectivity. Methods: Sixty-four participants were classified into a high NS group (n = 34) and a low NS group (n = 30) based on their total scores on the Chapman scales for physical and social anhedonia. All participants undertook a facial emotion discrimination functional imaging task that consisted of four emotional valences (angry, fear, happy, and neutral). For univariate analysis, the signal change at the bilateral amygdala was compared for each emotional contrast using SPSS (P < .05). For the functional connectivity analysis, we calculated the beta-series functional connectivity of the bilateral amygdala with the medial prefrontal cortex (mPFC) and compared the group differences in SPM12 (P < .05, small volume family-wise error correction). Results: No significant differences were found between the high and low NS groups in accuracy and reaction time in the facial emotion discrimination task. The high NS group showed reduced brain activations at the amygdala under fearful and neutral conditions. Reduced functional connectivity between the amygdala and the mPFC/dorsal anterior cingulate cortex under the happy and fearful conditions in the high NS group was also found. Conclusions: Our findings suggest that the individuals with high NS showed altered brain activity and functional connectivity at the amygdala during facial emotion processing and provide new evidence for understanding social cognition deficits in at-risk individuals.
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    Journal Title
    Schizophrenia Bulletin
    Volume
    44
    DOI
    https://doi.org/10.1093/schbul/sby036
    Copyright Statement
    © 2018 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Schizophrenia Bulletin following peer review. The definitive publisher-authenticated version Negative Schizotypy and Altered Functional Connectivity during Facial Emotion Processing, Schizophrenia Bulletin, Volume 44, Issue suppl_2, November 2018, Pages S491–S500 is available online at: 10.1093/schbul/sby036
    Subject
    Biomedical and clinical sciences
    Psychology
    Publication URI
    http://hdl.handle.net/10072/385642
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    • Journal articles

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