dc.contributor.author | Hofmann, Andreas | |
dc.contributor.author | Preston, Sarah | |
dc.contributor.author | Cross, Megan | |
dc.contributor.author | Herath, HMP Dilrukshi | |
dc.contributor.author | Simon, Anne | |
dc.contributor.author | Gasser, Robin B | |
dc.date.accessioned | 2019-07-02T12:31:35Z | |
dc.date.available | 2019-07-02T12:31:35Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1471-2105 | |
dc.identifier.doi | 10.1186/s12859-019-2891-5 | |
dc.identifier.uri | http://hdl.handle.net/10072/385700 | |
dc.description.abstract | Background:
Analyses of replicates in sets of discrete data, typically acquired in multi-well plate formats, is a recurring task in many contemporary areas in the Life Sciences. The availability of accessible cross-platform data analysis tools for such fundamental tasks in varied projects and environments is an important prerequisite to ensuring a reliable and timely turnaround as well as to provide practical analytical tools for student training.
Results:
We have developed an easy-to-use, interactive software tool for the analysis of multiple data sets comprising replicates of discrete bivariate data points. For each dataset, the software identifies the replicate data points from a defined matrix layout and calculates their means and standard errors. The averaged values are then automatically fitted using either a linear or a logistic dose response function.
Conclusions:
DRfit is a practical and convenient tool for the analysis of one or multiple sets of discrete data points acquired as replicates from multi-well plate assays. The design of the graphical user interface and the built-in analysis features make it a flexible and useful tool for a wide range of different assays. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | BMC | |
dc.relation.ispartofjournal | BMC BIOINFORMATICS | |
dc.relation.ispartofvolume | 20 | |
dc.subject.fieldofresearch | Mathematical sciences | |
dc.subject.fieldofresearch | Biological sciences | |
dc.subject.fieldofresearchcode | 49 | |
dc.subject.fieldofresearchcode | 31 | |
dc.title | DRfit: a Java tool for the analysis of discrete data from multi-well plate assays | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | http://creativecommons.org/licenses/by/4.0/ | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Hofmann, Andreas | |
gro.griffith.author | Cross, Megan O. | |