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  • Nipple Reconstruction: A Regenerative Medicine Approach Using 3D-Printed Tissue Scaffolds

    Author(s)
    Khoo, Denver
    Ung, Owen
    Blomberger, Daniela
    Hutmacher, Dietmar W
    Griffith University Author(s)
    Hutmacher, Dietmar W.
    Year published
    2019
    Metadata
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    Abstract
    Nipple–areola complex reconstruction is a common procedure that often accompanies breast reconstruction. Historically, local skin flaps were utilized for nipple reconstruction, with more recent techniques exploring the addition of implanted material. Tissue engineering and regenerative medicine (TE&RM) represents a potential source of stable and biocompatible implantable tissue, which may have a positive effect on cosmetic outcomes. Conventional TE&RM techniques involve seeding a scaffold with the patients' own cells and using growth factors to promote survival. The clinical applicability of these techniques is limited by ...
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    Nipple–areola complex reconstruction is a common procedure that often accompanies breast reconstruction. Historically, local skin flaps were utilized for nipple reconstruction, with more recent techniques exploring the addition of implanted material. Tissue engineering and regenerative medicine (TE&RM) represents a potential source of stable and biocompatible implantable tissue, which may have a positive effect on cosmetic outcomes. Conventional TE&RM techniques involve seeding a scaffold with the patients' own cells and using growth factors to promote survival. The clinical applicability of these techniques is limited by its cost and ability to produce sufficient volumes of viable tissue. This article reviews the evolution of nipple reconstruction techniques and current TE&RM protocols; these two fields are then combined to propose a novel approach of using TE&RM scaffolds to augment conventional nipple reconstruction.
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    Journal Title
    TISSUE ENGINEERING PART B-REVIEWS
    Volume
    25
    Issue
    2
    DOI
    https://doi.org/10.1089/ten.teb.2018.0253
    Subject
    Biochemistry and cell biology
    Biomedical engineering
    Publication URI
    http://hdl.handle.net/10072/385707
    Collection
    • Journal articles

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