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dc.contributor.authorArmstrong, James PK
dc.contributor.authorPuetzer, Jennifer L
dc.contributor.authorSerio, Andrea
dc.contributor.authorGuex, Anne Geraldine
dc.contributor.authorKapnisi, Michaella
dc.contributor.authorBreant, Alexandre
dc.contributor.authorZong, Yifan
dc.contributor.authorAssal, Valentine
dc.contributor.authorSkaalure, Stacey C
dc.contributor.authorKing, Oisin
dc.contributor.authorMurty, Tara
dc.contributor.authorMeinert, Christoph
dc.contributor.authorFranklin, Amanda C
dc.contributor.authorBassindale, Philip G
dc.contributor.authorNichols, Madeleine K
dc.contributor.authorTerracciano, Cesare M
dc.contributor.authorHutmacher, Dietmar W
dc.contributor.authorDrinkwater, Bruce W
dc.contributor.authorKlein, Travis J
dc.contributor.authorPerriman, Adam W
dc.contributor.authorStevens, Molly M
dc.date.accessioned2019-07-03T12:36:40Z
dc.date.available2019-07-03T12:36:40Z
dc.date.issued2018
dc.identifier.issn0935-9648
dc.identifier.doi10.1002/adma.201802649
dc.identifier.urihttp://hdl.handle.net/10072/385748
dc.description.abstractTissue engineering has offered unique opportunities for disease modeling and regenerative medicine; however, the success of these strategies is dependent on faithful reproduction of native cellular organization. Here, it is reported that ultrasound standing waves can be used to organize myoblast populations in material systems for the engineering of aligned muscle tissue constructs. Patterned muscle engineered using type I collagen hydrogels exhibits significant anisotropy in tensile strength, and under mechanical constraint, produced microscale alignment on a cell and fiber level. Moreover, acoustic patterning of myoblasts in gelatin methacryloyl hydrogels significantly enhances myofibrillogenesis and promotes the formation of muscle fibers containing aligned bundles of myotubes, with a width of 120–150 µm and a spacing of 180–220 µm. The ability to remotely pattern fibers of aligned myotubes without any material cues or complex fabrication procedures represents a significant advance in the field of muscle tissue engineering. In general, these results are the first instance of engineered cell fibers formed from the differentiation of acoustically patterned cells. It is anticipated that this versatile methodology can be applied to many complex tissue morphologies, with broader relevance for spatially organized cell cultures, organoid development, and bioelectronics.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWILEY-V C H VERLAG GMBH
dc.relation.ispartofissue43
dc.relation.ispartofjournalADVANCED MATERIALS
dc.relation.ispartofvolume30
dc.subject.fieldofresearchPhysical Sciences
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchcode02
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode09
dc.titleEngineering Anisotropic Muscle Tissue using Acoustic Cell Patterning
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and repro-duction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorHutmacher, Dietmar W.


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