Show simple item record

dc.contributor.authorLandgraf, Marietta
dc.contributor.authorMcGovern, Jacqui A
dc.contributor.authorFriedl, Peter
dc.contributor.authorHutmacher, Dietmar W
dc.date.accessioned2019-07-03T12:36:46Z
dc.date.available2019-07-03T12:36:46Z
dc.date.issued2018
dc.identifier.issn0167-7799
dc.identifier.doi10.1016/j.tibtech.2017.12.001
dc.identifier.urihttp://hdl.handle.net/10072/385752
dc.description.abstractThe laboratory mouse is widely considered as a valid and affordable model organism to study human disease. Attempts to improve the relevance of murine models for the investigation of human pathologies led to the development of various genetically engineered, xenograft and humanized mouse models. Nevertheless, most preclinical studies in mice suffer from insufficient predictive value when compared with cancer biology and therapy response of human patients. We propose an innovative strategy to improve the predictive power of preclinical cancer models. Combining (i) genomic, tissue engineering and regenerative medicine approaches for rational design of mouse models with (ii) rapid prototyping and computational benchmarking against human clinical data will enable fast and nonbiased validation of newly generated models.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier Science
dc.relation.ispartofpagefrom242
dc.relation.ispartofpageto251
dc.relation.ispartofissue3
dc.relation.ispartofjournalTRENDS IN BIOTECHNOLOGY
dc.relation.ispartofvolume36
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode40
dc.titleRational Design of Mouse Models for Cancer Research
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorHutmacher, Dietmar W.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record