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dc.contributor.authorWunner, Felix M
dc.contributor.authorWille, Marie-Luise
dc.contributor.authorNoonan, Thomas G
dc.contributor.authorBas, Onur
dc.contributor.authorDalton, Paul D
dc.contributor.authorDe-Juan-Pardo, Elena M
dc.contributor.authorHutmacher, Dietmar W
dc.date.accessioned2019-07-05T12:32:13Z
dc.date.available2019-07-05T12:32:13Z
dc.date.issued2018
dc.identifier.issn0935-9648
dc.identifier.doi10.1002/adma.201706570
dc.identifier.urihttp://hdl.handle.net/10072/385755
dc.description.abstractThe additive manufacturing of highly ordered, micrometer‐scale scaffolds is at the forefront of tissue engineering and regenerative medicine research. The fabrication of scaffolds for the regeneration of larger tissue volumes, in particular, remains a major challenge. A technology at the convergence of additive manufacturing and electrospinning–melt electrospinning writing (MEW)–is also limited in thickness/volume due to the accumulation of excess charge from the deposited material repelling and hence, distorting scaffold architectures. The underlying physical principles are studied that constrain MEW of thick, large volume scaffolds. Through computational modeling, numerical values variable working distances are established respectively, which maintain the electrostatic force at a constant level during the printing process. Based on the computational simulations, three voltage profiles are applied to determine the maximum height (exceeding 7 mm) of a highly ordered large volume scaffold. These thick MEW scaffolds have fully interconnected pores and allow cells to migrate and proliferate. To the best of the authors knowledge, this is the first study to report that z‐axis adjustment and increasing the voltage during the MEW process allows for the fabrication of high‐volume scaffolds with uniform morphologies and fiber diameters.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWILEY-V C H VERLAG GMBH
dc.relation.ispartofissue20
dc.relation.ispartofjournalADVANCED MATERIALS
dc.relation.ispartofvolume30
dc.subject.fieldofresearchPhysical Sciences
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchcode02
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode09
dc.titleMelt Electrospinning Writing of Highly Ordered Large Volume Scaffold Architectures
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorHutmacher, Dietmar W.


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