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dc.contributor.authorBas, Onur
dc.contributor.authorLucarotti, Sara
dc.contributor.authorAngella, Davide D
dc.contributor.authorCastro, Nathan J
dc.contributor.authorMeinert, Christoph
dc.contributor.authorWunner, Felix M
dc.contributor.authorRank, Ernst
dc.contributor.authorVozzi, Giovanni
dc.contributor.authorKlein, Travis J
dc.contributor.authorCatelas, Isabelle
dc.contributor.authorDe-Juan-Pardo, Elena M
dc.contributor.authorHutmacher, Dietmar W
dc.date.accessioned2019-07-05T12:32:20Z
dc.date.available2019-07-05T12:32:20Z
dc.date.issued2018
dc.identifier.issn1385-8947
dc.identifier.doi10.1016/j.cej.2018.01.020
dc.identifier.urihttp://hdl.handle.net/10072/385759
dc.description.abstractThere is an urgent need in the field of soft tissue engineering (STE) to develop biomaterials exhibiting a high degree of biological and mechanical functionality as well as modularity so that they can be tailored according to patient-specific requirements. Recently, biomimetic soft network composites (SNC) consisting of a water-swollen hydrogel matrix and a reinforcing fibrous network fabricated by melt electrospinning writing technology have demonstrated exceptional mechanical and biological properties, thus becoming strong candidates for STE applications. However, there is a lack of design approaches to tailor and optimize their properties in a non-empirical way. To address this challenge, we propose a numerical model-based approach for the rational design of patient-specific SNC for tissue engineering applications. The approach is rooted in an in silico design library that allows for the selection of biomaterial and architecture combinations for the target application, resulting in reduced time, manpower and costs. To demonstrate the validity of the design strategy, a multiphasic SNC with predefined zone-specific properties that captured the complex zonal mechanical and compositional features of articular cartilage was developed based on the natural design of the native tissue.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier Science
dc.relation.ispartofpagefrom15
dc.relation.ispartofpageto23
dc.relation.ispartofjournalCHEMICAL ENGINEERING JOURNAL
dc.relation.ispartofvolume340
dc.subject.fieldofresearchChemical engineering
dc.subject.fieldofresearchCivil engineering
dc.subject.fieldofresearchEnvironmental engineering
dc.subject.fieldofresearchcode4004
dc.subject.fieldofresearchcode4005
dc.subject.fieldofresearchcode4011
dc.titleRational design and fabrication of multiphasic soft network composites for tissue engineering articular cartilage: A numerical model-based approach
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorHutmacher, Dietmar W.


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