Death, TIR, and RHIM: Self-assembling domains involved in innate immunity and cell-death signaling
Author(s)
Nanson, Jeffrey D
Kobe, Bostjan
Ve, Thomas
Griffith University Author(s)
Year published
2019
Metadata
Show full item recordAbstract
The innate immune system consists of pattern recognition receptors (PRRs) that detect pathogen‐ and endogenous danger‐associated molecular patterns (PAMPs and DAMPs), initiating signaling pathways that lead to the induction of cytokine expression, processing of pro‐inflammatory cytokines, and induction of cell‐death responses. An emerging concept in these pathways and associated processes is signaling by cooperative assembly formation (SCAF), which involves formation of higher order oligomeric complexes, and enables rapid and strongly amplified signaling responses to minute amounts of stimulus. Many of these signalosomes ...
View more >The innate immune system consists of pattern recognition receptors (PRRs) that detect pathogen‐ and endogenous danger‐associated molecular patterns (PAMPs and DAMPs), initiating signaling pathways that lead to the induction of cytokine expression, processing of pro‐inflammatory cytokines, and induction of cell‐death responses. An emerging concept in these pathways and associated processes is signaling by cooperative assembly formation (SCAF), which involves formation of higher order oligomeric complexes, and enables rapid and strongly amplified signaling responses to minute amounts of stimulus. Many of these signalosomes assemble through homotypic interactions of members of the death‐fold (DF) superfamily, Toll/IL‐1 receptor (TIR) domains, or the RIP homotypic interaction motifs (RHIM). We review the current understanding of the structure and function of these domains and their molecular interactions with a particular focus on higher order assemblies.
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View more >The innate immune system consists of pattern recognition receptors (PRRs) that detect pathogen‐ and endogenous danger‐associated molecular patterns (PAMPs and DAMPs), initiating signaling pathways that lead to the induction of cytokine expression, processing of pro‐inflammatory cytokines, and induction of cell‐death responses. An emerging concept in these pathways and associated processes is signaling by cooperative assembly formation (SCAF), which involves formation of higher order oligomeric complexes, and enables rapid and strongly amplified signaling responses to minute amounts of stimulus. Many of these signalosomes assemble through homotypic interactions of members of the death‐fold (DF) superfamily, Toll/IL‐1 receptor (TIR) domains, or the RIP homotypic interaction motifs (RHIM). We review the current understanding of the structure and function of these domains and their molecular interactions with a particular focus on higher order assemblies.
View less >
Journal Title
JOURNAL OF LEUKOCYTE BIOLOGY
Volume
105
Issue
2
Subject
Biochemistry and cell biology
Immunology