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dc.contributor.authorSantander-Borrego, Miriem
dc.contributor.authorChirila, Traian V
dc.contributor.authorShadforth, Audra MA
dc.contributor.authorWhittaker, Andrew K
dc.contributor.authorBlakey, Idriss
dc.date.accessioned2019-07-11T03:03:19Z
dc.date.available2019-07-11T03:03:19Z
dc.date.issued2018
dc.identifier.issn0883-9115
dc.identifier.doi10.1177/0883911517744572
dc.identifier.urihttp://hdl.handle.net/10072/385847
dc.description.abstractThe effects on cell adhesion induced by changes in the topography and chemistry of poly(2- hydroxyethyl methacrylate) hydrogel surfaces were investigated in vitro using the human corneal epithelial cell line, HCE-T. Poly(2-hydroxyethyl methacrylate) surfaces with a lotusleaf-like topography and poly(2-hydroxyethyl methacrylate) surfaces with a flat topography, but functionalized with the cell-adhesive peptide sequence Arg–Gly–Asp, both enhanced attachment of HCE-T cells as compared to flat, non-functionalized poly(2-hydroxyethyl methacrylate) surfaces. However, the simultaneous existence on the same poly(2-hydroxyethyl methacrylate) surface of Arg–Gly–Asp motifs and of lotus-leaf-like topographical patterns led to an apparently antagonistic effect reflected in reduced cell attachment. The study provided additional evidence of the complexity of the cell–biomaterial interactions.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS LTD
dc.relation.ispartofpagefrom321
dc.relation.ispartofpageto331
dc.relation.ispartofissue3
dc.relation.ispartofjournalJOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
dc.relation.ispartofvolume33
dc.subject.fieldofresearchMacromolecular and materials chemistry
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchcode3403
dc.subject.fieldofresearchcode4003
dc.titleEffect of changes in the surface chemistry and topography of poly(2-hydroxyethyl methacrylate) on the in vitro attachment of human corneal epithelial cells
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorShadforth, Audra


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