dc.contributor.author | Santander-Borrego, Miriem | |
dc.contributor.author | Chirila, Traian V | |
dc.contributor.author | Shadforth, Audra MA | |
dc.contributor.author | Whittaker, Andrew K | |
dc.contributor.author | Blakey, Idriss | |
dc.date.accessioned | 2019-07-11T03:03:19Z | |
dc.date.available | 2019-07-11T03:03:19Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0883-9115 | |
dc.identifier.doi | 10.1177/0883911517744572 | |
dc.identifier.uri | http://hdl.handle.net/10072/385847 | |
dc.description.abstract | The effects on cell adhesion induced by changes in the topography and chemistry of poly(2-
hydroxyethyl methacrylate) hydrogel surfaces were investigated in vitro using the human
corneal epithelial cell line, HCE-T. Poly(2-hydroxyethyl methacrylate) surfaces with a lotusleaf-like topography and poly(2-hydroxyethyl methacrylate) surfaces with a flat topography, but
functionalized with the cell-adhesive peptide sequence Arg–Gly–Asp, both enhanced attachment
of HCE-T cells as compared to flat, non-functionalized poly(2-hydroxyethyl methacrylate)
surfaces. However, the simultaneous existence on the same poly(2-hydroxyethyl methacrylate)
surface of Arg–Gly–Asp motifs and of lotus-leaf-like topographical patterns led to an apparently
antagonistic effect reflected in reduced cell attachment. The study provided additional evidence
of the complexity of the cell–biomaterial interactions. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | SAGE PUBLICATIONS LTD | |
dc.relation.ispartofpagefrom | 321 | |
dc.relation.ispartofpageto | 331 | |
dc.relation.ispartofissue | 3 | |
dc.relation.ispartofjournal | JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | |
dc.relation.ispartofvolume | 33 | |
dc.subject.fieldofresearch | Macromolecular and materials chemistry | |
dc.subject.fieldofresearch | Biomedical engineering | |
dc.subject.fieldofresearchcode | 3403 | |
dc.subject.fieldofresearchcode | 4003 | |
dc.title | Effect of changes in the surface chemistry and topography of poly(2-hydroxyethyl methacrylate) on the in vitro attachment of human corneal epithelial cells | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Shadforth, Audra | |