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dc.contributor.authorSimerska, Pavla
dc.contributor.authorAbdel-Aal, Abu-Baker M.
dc.contributor.authorFujita, Yoshio
dc.contributor.authorBatzloff, Michael R.
dc.contributor.authorGood, Michael F.
dc.contributor.authorToth, Istvan
dc.date.accessioned2017-05-03T12:54:00Z
dc.date.available2017-05-03T12:54:00Z
dc.date.issued2008
dc.date.modified2014-01-08T05:31:00Z
dc.identifier.issn00063525
dc.identifier.doi10.1002/bip.20992
dc.identifier.urihttp://hdl.handle.net/10072/38589
dc.description.abstractCarbohydrates, as carriers, providing numerous attachment points for the conjugation of peptide antigens and their optimal orientation for the recognition by cells of the immune system, reducing degradation of the attached peptide antigens and many other advantages make carbohydrate-based vaccine highly promising approach. Multiple copies of a single group A streptococcal (GAS) M protein derived specific peptide antigens (J8 or J14) were coupled onto carbohydrate cores (D-glucose and D-galactose) linked to lipophilic amino acids to produce a self-adjuvanting liposaccharide vaccine against GAS strains. In vivo experiments showed high serum IgG antibody titers against each of the incorporated peptide epitopes, J8 or J14.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley Interscience
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom611
dc.relation.ispartofpageto616
dc.relation.ispartofissue5
dc.relation.ispartofjournalBiopolymers
dc.relation.ispartofvolume90
dc.rights.retentionY
dc.subject.fieldofresearchInfectious Agents
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchcode060502
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode06
dc.titleSynthesis and in vivo studies of carbohydrate-based vaccines against group A streptococcus
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorBatzloff, Michael R.


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