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  • Elemental Metabolomics and Pregnancy Outcomes

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    MCKEATING182691.pdf (599.4Kb)
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    Author(s)
    McKeating, Daniel R
    Fisher, Joshua J
    Perkins, Anthony V
    Griffith University Author(s)
    McKeating, Daniel R.
    Fisher, Joshua
    Perkins, Anthony V.
    Year published
    2019
    Metadata
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    Abstract
    Trace elements are important for human health and development. The body requires specific micronutrients to function, with aberrant changes associated with a variety of negative health outcomes. Despite this evidence, the status and function of micronutrients during pregnancy are relatively unknown and more information is required to ensure that women receive optimal intakes for foetal development. Changes in trace element status have been associated with pregnancy complications such as gestational diabetes mellitus (GDM), pre-eclampsia (PE), intrauterine growth restriction (IUGR), and preterm birth. Measuring micronutrients ...
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    Trace elements are important for human health and development. The body requires specific micronutrients to function, with aberrant changes associated with a variety of negative health outcomes. Despite this evidence, the status and function of micronutrients during pregnancy are relatively unknown and more information is required to ensure that women receive optimal intakes for foetal development. Changes in trace element status have been associated with pregnancy complications such as gestational diabetes mellitus (GDM), pre-eclampsia (PE), intrauterine growth restriction (IUGR), and preterm birth. Measuring micronutrients with methodologies such as elemental metabolomics, which involves the simultaneous quantification and characterisation of multiple elements, could provide insight into gestational disorders. Identifying unique and subtle micronutrient changes may highlight associated proteins that are affected underpinning the pathophysiology of these complications, leading to new means of disease diagnosis. This review will provide a comprehensive summary of micronutrient status during pregnancy, and their associations with gestational disorders. Furthermore, it will also comment on the potential use of elemental metabolomics as a technique for disease characterisation and prediction.
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    Journal Title
    NUTRIENTS
    Volume
    11
    Issue
    1
    DOI
    https://doi.org/10.3390/nu11010073
    Copyright Statement
    © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
    Subject
    Food sciences
    Nutrition and dietetics
    Publication URI
    http://hdl.handle.net/10072/385990
    Collection
    • Journal articles

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