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dc.contributor.authorHall, Michelle
dc.contributor.authorCastelein, Birgit
dc.contributor.authorWittoek, Ruth
dc.contributor.authorCalders, Patrick
dc.contributor.authorVan Ginckel, Ans
dc.date.accessioned2019-07-11T12:31:40Z
dc.date.available2019-07-11T12:31:40Z
dc.date.issued2019
dc.identifier.issn0049-0172
dc.identifier.doi10.1016/j.semarthrit.2018.06.005
dc.identifier.urihttp://hdl.handle.net/10072/386022
dc.description.abstractObjectives: The purposes were to (i) determine the effect of diet-only treatments and combined diet and exercise treatments on pain and physical function and (ii) explore the effect of these treatments on inflammatory biomarkers in overweight and obese adults with knee osteoarthritis. Methods: Five electronic databases were searched until March 2017. Randomised controlled trials investigating the effect of non-surgical non-pharmacological weight loss treatment, with or without exercise, on self-reported pain and/or physical function and/or inflammatory biomarkers were selected. Two review authors independently extracted data and assessed risk of bias for each study. Standardised mean differences (SMD) of outcomes were pooled as appropriate, using a random effects approach. Results: 2676 articles were identified, 19 met review criteria and 9 met criteria for meta-analyses. Diet-only treatments did not reduce pain (SMD −0.13; 95% confidence interval, CI: −0.37, 0.10; I2 = 49%) while a combination of diet and exercise treatments did reduce pain moderately (SMD −0.37; 95%CI: −0.69, −0.04; I2 = 54%). Physical function improved moderately with diet treatments (SMD −0.30; 95%CI: −0.52, −0.08; I2 = 47%) and combined diet and exercise treatments (SMD −0.32; 95%CI: −0.56, −0.08; I2 = 24%). Of the inflammatory markers assessed, only IL-6 reduced with diet-only treatments (SMD −0.23; 95%CI: −0.45, −0.02; I2 = 0%). Conclusion: Overall, moderate pain-relief is achievable with a combination of diet and exercise, but potentially not with diet-only treatments. Findings support that either diet-only treatments or combined diet and exercise treatments moderately improve physical function. Overall, treatment effects on inflammatory biomarkers are questionable.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherW B SAUNDERS CO-ELSEVIER INC
dc.relation.ispartofpagefrom765
dc.relation.ispartofpageto777
dc.relation.ispartofissue5
dc.relation.ispartofjournalSEMINARS IN ARTHRITIS AND RHEUMATISM
dc.relation.ispartofvolume48
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1117
dc.titleDiet-induced weight loss alone or combined with exercise in overweight or obese people with knee osteoarthritis: A systematic review and meta-analysis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorHall, Michelle


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