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dc.contributor.authorMcLeary, Fleur
dc.contributor.authorDavis, Arie
dc.contributor.authorRudrawar, Santosh
dc.contributor.authorPerkins, Anthony
dc.contributor.authorAnoopkumar-Dukie, Shailendra
dc.date.accessioned2019-07-03T12:34:16Z
dc.date.available2019-07-03T12:34:16Z
dc.date.issued2019
dc.identifier.issn0014-2999
dc.identifier.doi10.1016/j.ejphar.2018.09.034
dc.identifier.urihttp://hdl.handle.net/10072/386040
dc.description.abstractThis review demonstrates the importance of uncovering the mechanisms that underlie chemotherapy-induced neuroinflammation. It builds upon the well-established connection between chemotherapeutic-agents and neurotoxicity along with widespread peripheral toxicities. This article summarises the major studies which have linked chemotherapy-induced neurodegeneration with direct evidence of neuroinflammation. Cancer and chemotherapy-related adverse effects impact a large proportion of the population. A better understanding of the link between chemotherapy, neurotoxicity and specifically the mechanisms of neuroinflammation, will allow the development of strategies to improve the management of side effects, and overall to reduce the burden on cancer patients receiving chemotherapy. This review has developed a summary schematic of the relationship between different chemotherapeutic agents and inflammatory markers within the central nervous system and links this correlation with some major ailments associated with chemotherapy use.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier
dc.relation.ispartofpagefrom49
dc.relation.ispartofpageto56
dc.relation.ispartofjournalEuropean Journal of Pharmacology
dc.relation.ispartofvolume842
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchArtificial Intelligence and Image Processing
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode1115
dc.subject.fieldofresearchcode0801
dc.subject.fieldofresearchcode1701
dc.subject.fieldofresearchcode1702
dc.titleMechanisms underlying select chemotherapeutic-agent-induced neuroinflammation and subsequent neurodegeneration
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2019 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorAnoopkumar-Dukie, Shailendra
gro.griffith.authorRudrawar, Santosh
gro.griffith.authorMcLeary, Fleur A.
gro.griffith.authorDavis, Arie J.
gro.griffith.authorPerkins, Anthony V.


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