Cancer Stem Cells: Role in Tumor Progression and Treatment Resistance
Author(s)
Islam, Farhadul
Gopalan, Vinod
Lam, Alfred King-Yin
Year published
2019
Metadata
Show full item recordAbstract
Cancer stem cells (CSCs) or cancer initiating cells are a subpopulation of cells that has the driving force of carcinogenesis. They exhibit distinctive self-renewal, proliferation, and differentiation capabilities that are believed to play a critical role in cancer initiation, maintenance, progression, drug resistance, and cancer recurrence or metastasis. Factors such as increased activation of drug-efflux pumps, enhanced capacity of DNA damage repair, dysregulation of growth and developmental signaling pathways, alterations of cellular metabolism, environmental niche, and impaired apoptotic response are attributed to CSCs ...
View more >Cancer stem cells (CSCs) or cancer initiating cells are a subpopulation of cells that has the driving force of carcinogenesis. They exhibit distinctive self-renewal, proliferation, and differentiation capabilities that are believed to play a critical role in cancer initiation, maintenance, progression, drug resistance, and cancer recurrence or metastasis. Factors such as increased activation of drug-efflux pumps, enhanced capacity of DNA damage repair, dysregulation of growth and developmental signaling pathways, alterations of cellular metabolism, environmental niche, and impaired apoptotic response are attributed to CSCs in their resistance to the adjuvant chemoradiotherapy to cancer. The development of strategies targeting CSCs via drug transporters, specific surface markers, inhibiting signaling pathways or their components, and destroying their tumor microenvironment have multifocal effects that may improve the clinical outcome of patients with cancer.
View less >
View more >Cancer stem cells (CSCs) or cancer initiating cells are a subpopulation of cells that has the driving force of carcinogenesis. They exhibit distinctive self-renewal, proliferation, and differentiation capabilities that are believed to play a critical role in cancer initiation, maintenance, progression, drug resistance, and cancer recurrence or metastasis. Factors such as increased activation of drug-efflux pumps, enhanced capacity of DNA damage repair, dysregulation of growth and developmental signaling pathways, alterations of cellular metabolism, environmental niche, and impaired apoptotic response are attributed to CSCs in their resistance to the adjuvant chemoradiotherapy to cancer. The development of strategies targeting CSCs via drug transporters, specific surface markers, inhibiting signaling pathways or their components, and destroying their tumor microenvironment have multifocal effects that may improve the clinical outcome of patients with cancer.
View less >
Book Title
Oncogenomics: From Basic Research to Precision Medicine
Subject
Oncology and carcinogenesis
Biomedical and clinical sciences