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dc.contributor.authorKing, Eleanor
dc.contributor.authorO'Brien, John
dc.contributor.authorDonaghy, Paul
dc.contributor.authorWilliams-Gray, Caroline H
dc.contributor.authorLawson, Rachael A
dc.contributor.authorMorris, Christopher M
dc.contributor.authorBarnett, Nicola
dc.contributor.authorOlsen, Kirsty
dc.contributor.authorMartin-Ruiz, Carmen
dc.contributor.authorBurn, David
dc.contributor.authorYarnall, Alison J
dc.contributor.authorTaylor, John-Paul
dc.contributor.authorDuncan, Gordan
dc.contributor.authorKhoo, Tien K
dc.contributor.authorThomas, Alan
dc.date.accessioned2019-07-05T05:58:25Z
dc.date.available2019-07-05T05:58:25Z
dc.date.issued2019
dc.identifier.issn0885-6230
dc.identifier.doi10.1002/gps.5124
dc.identifier.urihttp://hdl.handle.net/10072/386201
dc.description.abstractBackground: Inflammation appears to play a role in the progression of neurodegenerative diseases. However, little is known about inflammation during early stages of cognitive decline or whether this differs in different disease groups. We sought to investigate this by assessing the inflammatory profile in patients with Parkinson disease with the early stages of cognitive impairment (PD-MCI), patients with prodromal Alzheimer disease (MCI-AD), prodromal Lewy body disease (MCI-LB), and controls. Methods: We obtained venous blood samples from participants with PD-MCI (n = 44), PD-normal cognition (n = 112), MCI-LB (n = 38), MCI-AD (n = 21), and controls (n = 84). We measured 10 cytokines using Meso Scale Discovery V-Plex Plus including interferon gamma, interleukin (IL)-10, IL-12p70, IL-13, IL-1beta, IL-2, IL-4, IL-6, IL-8, and tumour necrosis factor alpha. High-sensitivity C-reactive protein was measured. Results: There was a higher level of inflammation in patients with MCI-AD and MCI-LB compared with controls. PD noncognitively impaired had higher inflammatory markers than controls, but there was no difference between PD-MCI and controls. There was a decrease in inflammatory markers with increasing motor severity based on the Unified Parkinson's Disease Rating Scale. Conclusions: Inflammation may be involved in the onset of cognitive decline in patients with MCI-AD and MCI-LB but appears to be less prominent PD-MCI albeit in a small data set. This suggests that anti-inflammatory medications may have most benefit at the earliest stages of neurodegenerative diseases. For PD cases, this might be in advance of the development of MCI.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofjournalInternational Journal of Geriatric Psychiatry
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode52
dc.subject.fieldofresearchcode5204
dc.titleInflammation in mild cognitive impairment due to Parkinson's disease, Lewy body disease, and Alzheimer's disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.hasfulltextNo Full Text
gro.griffith.authorKhoo, Tien Kheng


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