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dc.contributor.authorZhou, Y
dc.contributor.authorChen, M
dc.contributor.authorSimpson, S
dc.contributor.authorLucas, RM
dc.contributor.authorCharlesworth, JC
dc.contributor.authorBlackburn, N
dc.contributor.authorvan der Mei, I
dc.contributor.authorPonsonby, AL
dc.contributor.authorTaylor, BV
dc.contributor.authorDear, K
dc.contributor.authorDwyer, T
dc.contributor.authorBlizzard, L
dc.contributor.authorSimpson, S
dc.contributor.authorBroadley, S
dc.contributor.authorKilpatrick, T
dc.contributor.authorWilliams, D
dc.contributor.authorLechner-Scott, J
dc.contributor.authorShaw, C
dc.contributor.authorChapman, C
dc.contributor.authorCoulthard, A
dc.contributor.authorValery, P
dc.date.accessioned2019-07-08T00:45:40Z
dc.date.available2019-07-08T00:45:40Z
dc.date.issued2018
dc.identifier.issn1590-1874
dc.identifier.doi10.1007/s10072-017-3177-1
dc.identifier.urihttp://hdl.handle.net/10072/386209
dc.description.abstractDespite extensive studies focusing on the changes in expression of microRNAs (miRNAs) in multiple sclerosis (MS) compared to healthy controls, few studies have evaluated the association of genetic variants of miRNAs with MS clinical course. We investigated whether a functional polymorphism in the MS associated miR-146a gene predicted clinical course (hazard of conversion to MS and of relapse, and annualized change in disability), using a longitudinal cohort study of persons with a first demyelinating event followed up to their 5-year review. We found the genotype (GC+CC) of rs2910164 predicted relapse compared with the GG genotype (HR=2.09 (95% CI 1.42, 3.06), p=0.0001), as well as a near-significant (p=0.07) association with MS conversion risk. Moreover, we found a significant additive interaction between rs2910164 and baseline anti-EBNA-1 IgG titers predicting risk of conversion to MS (relative excess risk due to interaction [RERI] 2.39, p=0.00002) and of relapse (RERI 1.20, p=0.006). Supporting these results, similar results were seen for the other EBV-correlated variables: anti-EBNA-2 IgG titers and past history of infectious mononucleosis. There was no association of rs2910164 genotype for disability progression. Our findings provide evidence for miR-146a and EBV infection in modulating MS clinical course.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofpagefrom297
dc.relation.ispartofpageto304
dc.relation.ispartofissue2
dc.relation.ispartofjournalNeurological Sciences
dc.relation.ispartofvolume39
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3209
dc.titleCommon genetic variation within miR-146a predicts disease onset and relapse in multiple sclerosis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorBroadley, Simon


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