Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines

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Author(s)
Ssemaganda, Aloysious
Giddam, Ashwini Kumar
Zaman, Mehfuz
Skwarczynski, Mariusz
Toth, Istvan
Stanisic, Danielle I
Good, Michael F
Griffith University Author(s)
Year published
2019
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Abstract
In the development of vaccines, the ability to initiate both innate and subsequent adaptive immune responses need to be considered. Live attenuated vaccines achieve this naturally, while inactivated and sub-unit vaccines generally require additional help provided through delivery systems and/or adjuvants. Liposomes present an attractive adjuvant/delivery system for antigens. Here, we review the key aspects of immunity against Plasmodium parasites, liposome design considerations and their current application in the development of a malaria vaccine.
Journal Title
FRONTIERS IN IMMUNOLOGY
Volume
10
DOI
Copyright Statement
© 2019 Ssemaganda, Giddam, Zaman, Skwarczynski, Toth, Stanisic and Good. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Subject
Immunology
Medical Microbiology
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