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  • Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines

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    GOOD197387.pdf (558.0Kb)
    Author(s)
    Ssemaganda, Aloysious
    Giddam, Ashwini Kumar
    Zaman, Mehfuz
    Skwarczynski, Mariusz
    Toth, Istvan
    Stanisic, Danielle I
    Good, Michael F
    Griffith University Author(s)
    Good, Michael F.
    Stanisic, Danielle
    Zaman, Mehfuz
    Year published
    2019
    Metadata
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    Abstract
    In the development of vaccines, the ability to initiate both innate and subsequent adaptive immune responses need to be considered. Live attenuated vaccines achieve this naturally, while inactivated and sub-unit vaccines generally require additional help provided through delivery systems and/or adjuvants. Liposomes present an attractive adjuvant/delivery system for antigens. Here, we review the key aspects of immunity against Plasmodium parasites, liposome design considerations and their current application in the development of a malaria vaccine.In the development of vaccines, the ability to initiate both innate and subsequent adaptive immune responses need to be considered. Live attenuated vaccines achieve this naturally, while inactivated and sub-unit vaccines generally require additional help provided through delivery systems and/or adjuvants. Liposomes present an attractive adjuvant/delivery system for antigens. Here, we review the key aspects of immunity against Plasmodium parasites, liposome design considerations and their current application in the development of a malaria vaccine.
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    Journal Title
    FRONTIERS IN IMMUNOLOGY
    Volume
    10
    DOI
    https://doi.org/10.3389/fimmu.2019.00135
    Copyright Statement
    © 2019 Ssemaganda, Giddam, Zaman, Skwarczynski, Toth, Stanisic and Good. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
    Subject
    Immunology
    Medical Microbiology
    Publication URI
    http://hdl.handle.net/10072/386307
    Collection
    • Journal articles

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