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  • Research priorities and potential methodologies to inform care in subsequent pregnancies following stillbirth: a web-based survey of healthcare professionals, researchers and advocates

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    Ellwood232819.pdf (560.0Kb)
    Author(s)
    Wojcieszek, AM
    Heazell, AEPP
    Middleton, P
    Ellwood, D
    Silver, RM
    Flenady, V
    Griffith University Author(s)
    Ellwood, David
    Year published
    2019
    Metadata
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    Abstract
    Objectives: To identify research priorities and explore potential methodologies to inform care in subsequent pregnancies following a stillbirth. Design: Web-based survey by invitation. Participants: Multidisciplinary panel of 79 individuals involved in stillbirth research, clinical practice and/or advocacy from the international stillbirth research community (response rate=64%). Outcome measures: Importance of 16 candidate research topics and perceived utility and appropriateness of randomised controlled trial (RCT) methodology for the evaluation of four pertinent interventions: (1) medical therapies for placental dysfunction ...
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    Objectives: To identify research priorities and explore potential methodologies to inform care in subsequent pregnancies following a stillbirth. Design: Web-based survey by invitation. Participants: Multidisciplinary panel of 79 individuals involved in stillbirth research, clinical practice and/or advocacy from the international stillbirth research community (response rate=64%). Outcome measures: Importance of 16 candidate research topics and perceived utility and appropriateness of randomised controlled trial (RCT) methodology for the evaluation of four pertinent interventions: (1) medical therapies for placental dysfunction (eg, antiplatelet agents); (2) additional antepartum fetal surveillance (eg, ultrasound scans); (3) early planned birth from 37 weeks’ gestation and (4) different forms of psychosocial support for parents and families. Results: Candidate research topics that were rated as ‘important and urgent’ by the greatest proportion of participants were: medical therapies for placental dysfunction (81%); additional antepartum fetal surveillance (80%); the development of a core outcomes dataset for stillbirth research (79%); targeted antenatal interventions for women who have risk factors (79%) and calculating the risk of recurrent stillbirth according to specific causes of index stillbirth (79%). Whether RCT methodologies were considered appropriate for the four selected interventions varied depending on the criterion being assessed. For example, while 72% of respondents felt that RCTs were ‘the best way’ to evaluate medical therapies for placental dysfunction, fewer respondents (63%) deemed RCTs ethical in this context, and approximately only half (52%) felt that such RCTs were feasible. There was considerably less support for RCT methodology for the evaluation of different forms of psychosocial support, which was reinforced by free-text comments. Conclusions: Five priority research topics to inform care in pregnancies after stillbirth were identified. There was support for RCTs in this area, but the panel remained divided on the ethics and feasibility of such trials. Engagement with parents and families is a critical next step
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    Journal Title
    BMJ Open
    Volume
    9
    Issue
    6
    DOI
    https://doi.org/10.1136/bmjopen-2018-028735
    Copyright Statement
    © 2019 The Authors. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial.
    Subject
    Medical and Health Sciences
    Clinical Sciences
    Public Health and Health Services
    Other Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/386368
    Collection
    • Journal articles

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