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dc.contributor.authorHe, Liangcan
dc.contributor.authorPang, Kanglei
dc.contributor.authorLiu, Wenwen
dc.contributor.authorTian, Yue
dc.contributor.authorChang, Lin
dc.contributor.authorLiu, Xu
dc.contributor.authorZhao, Meiting
dc.contributor.authorLiu, Yong
dc.contributor.authorLi, Yantao
dc.contributor.authorJiang, Xingyu
dc.contributor.authorSong, Rui
dc.contributor.authorLiu, Yaling
dc.date.accessioned2019-07-16T00:55:24Z
dc.date.available2019-07-16T00:55:24Z
dc.date.issued2019
dc.identifier.issn2050-750X
dc.identifier.doi10.1039/c8tb03318h
dc.identifier.urihttp://hdl.handle.net/10072/386452
dc.description.abstractCore–shell Au@zeolitic-imidazolate-framework-8 (ZIF-8) nanostructures are reported as a nanocarrier with both a high drug payload and high cancer treatment efficiency in vitro. Impressively, when used as multifunctional drug delivery vehicles, such core–shell Au@ZIF-8 nanostructures not only exhibit light- and pH-controlled drug release properties, but also provide two synergetic therapeutic modes for cancer treatment, resulting in 98% cell-killing activity after 30 min light irradiation followed by 24 h incubation even though HeLa cells are treated only by Au@ZIF-8 nanostructures loaded with 10 μM doxorubicin hydrochloride. All these results demonstrate the promising applications of this type of core–shell nanostructure in biomedical fields.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRoyal Society of Chemistry (RSC)
dc.relation.ispartofpagefrom1050
dc.relation.ispartofpageto1055
dc.relation.ispartofissue7
dc.relation.ispartofjournalJournal of Materials Chemistry B
dc.relation.ispartofvolume7
dc.subject.fieldofresearchBiomedical Engineering
dc.subject.fieldofresearchMacromolecular and Materials Chemistry
dc.subject.fieldofresearchcode0903
dc.subject.fieldofresearchcode0303
dc.titleCore–shell noble-metal@zeolitic-imidazolate-framework nanocarriers with high cancer treatment efficiency in vitro
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorLi, Yantao


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