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  • Role of Nanoparticle Mechanical Properties in Cancer Drug Delivery

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    Wibowo233694.pdf (1.259Mb)
    Author(s)
    Hui, Yue
    Yi, Xin
    Hou, Fei
    Wibowo, David
    Zhang, Fan
    Zhao, Dongyuan
    Gao, Huajian
    Zhao, Chun-Xia
    Griffith University Author(s)
    Wibowo, David
    Zhao, Dongyuan
    Year published
    2019
    Metadata
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    Abstract
    The physicochemical properties of nanoparticles play critical roles in regulating nano-bio interactions. Whereas the effects of the size, shape, and surface charge of nanoparticles on their biological performances have been extensively investigated, the roles of nanoparticle mechanical properties in drug delivery, which have only been recognized recently, remain the least explored. This review article provides an overview of the impacts of nanoparticle mechanical properties on cancer drug delivery, including (1) basic terminologies of the mechanical properties of nanoparticles and techniques for characterizing these properties; ...
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    The physicochemical properties of nanoparticles play critical roles in regulating nano-bio interactions. Whereas the effects of the size, shape, and surface charge of nanoparticles on their biological performances have been extensively investigated, the roles of nanoparticle mechanical properties in drug delivery, which have only been recognized recently, remain the least explored. This review article provides an overview of the impacts of nanoparticle mechanical properties on cancer drug delivery, including (1) basic terminologies of the mechanical properties of nanoparticles and techniques for characterizing these properties; (2) current methods for fabricating nanoparticles with tunable mechanical properties; (3) in vitro and in vivo studies that highlight key biological performances of stiff and soft nanoparticles, including blood circulation, tumor or tissue targeting, tumor penetration, and cancer cell internalization, with a special emphasis on the underlying mechanisms that control those complicated nano-bio interactions at the cellular, tissue, and organ levels. The interesting research and findings discussed in this review article will offer the research community a better understanding of how this research field evolved during the past years and provide some general guidance on how to design and explore the effects of nanoparticle mechanical properties on nano-bio interactions. These fundamental understandings, will in turn, improve our ability to design better nanoparticles for enhanced drug delivery.
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    Journal Title
    ACS Nano
    Volume
    13
    Issue
    7
    DOI
    https://doi.org/10.1021/acsnano.9b03924
    Copyright Statement
    © 2019 American Chemical Society. This document is the Postprint: Accepted Manuscript version of a Published Work that appeared in final form in the Journal of the American Chemical Society, 2019, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsnano.9b03924
    Subject
    Oncology and Carcinogenesis
    Young’s modulus
    Blood circulation
    Cellular uptake
    Drug delivery
    Elasticity
    Publication URI
    http://hdl.handle.net/10072/386485
    Collection
    • Journal articles

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