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  • Bioinspired Core-Shell Nanoparticles for Hydrophobic Drug Delivery

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    Wibowo246777.pdf (977.4Kb)
    Author(s)
    Yang, Guangze
    Liu, Yun
    Wang, Haofei
    Wilson, Russell
    Hui, Yue
    Yu, Alice
    Wibowo, David
    Zhang, Cheng
    Whittaker, Andrew
    Middelberg, Anton
    Zhao, Chun-Xia
    Griffith University Author(s)
    Wibowo, David
    Year published
    2019
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    Abstract
    With 40% of approved drugs and 90% of drugs in the pipeline being insoluble in water, developing methods to formulate and deliver hydrophobic drugs becomes urgent but remains a challenge. A large range of nanoparticles have been developed to encapsulate hydrophobic drugs. However, drug loading is usually less than 10% or even 1%. Herein, we report the fabrication of core‐shell nanoparticles having exceptionally high drug loading up to 65% (drug weight/the total weight of drug‐loaded nanoparticles) and high encapsulation efficiencies (>99%) based on modular biomolecule templating. Bifunctional amphiphilic peptides are designed ...
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    With 40% of approved drugs and 90% of drugs in the pipeline being insoluble in water, developing methods to formulate and deliver hydrophobic drugs becomes urgent but remains a challenge. A large range of nanoparticles have been developed to encapsulate hydrophobic drugs. However, drug loading is usually less than 10% or even 1%. Herein, we report the fabrication of core‐shell nanoparticles having exceptionally high drug loading up to 65% (drug weight/the total weight of drug‐loaded nanoparticles) and high encapsulation efficiencies (>99%) based on modular biomolecule templating. Bifunctional amphiphilic peptides are designed to not only stabilize hydrophobic drug nanoparticles but also induce biosilicification at the nanodrug particle surface thus forming drug‐core silica‐shell nanocomposites. This platform technology is highly versatile for encapsulating various hydrophobic cargos. Furthermore, the high drug loading nanoparticles lead to better in vitro cytotoxic effects and in vivo suppression of tumor growth, highlighting the significance of using high drug loading nanoparticles.
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    Journal Title
    Angewandte Chemie International Edition
    DOI
    https://doi.org/10.1002/anie.201908357
    Copyright Statement
    © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Bioinspired Core-Shell Nanoparticles for Hydrophobic Drug Delivery, Angewandte Chemie, International Edition, which has been published in final form at 10.1002/anie.201908357. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
    Subject
    Macromolecular and Materials Chemistry
    Biomaterials
    Nanobiotechnology
    Chemical Sciences
    Publication URI
    http://hdl.handle.net/10072/386589
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    • Journal articles

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