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dc.contributor.authorYang, Guangze
dc.contributor.authorLiu, Yun
dc.contributor.authorWang, Haofei
dc.contributor.authorWilson, Russell
dc.contributor.authorHui, Yue
dc.contributor.authorYu, Alice
dc.contributor.authorWibowo, David
dc.contributor.authorZhang, Cheng
dc.contributor.authorWhittaker, Andrew
dc.contributor.authorMiddelberg, Anton
dc.contributor.authorZhao, Chun-Xia
dc.date.accessioned2019-08-15T03:02:35Z
dc.date.available2019-08-15T03:02:35Z
dc.date.issued2019
dc.identifier.issn1433-7851
dc.identifier.doi10.1002/anie.201908357
dc.identifier.urihttp://hdl.handle.net/10072/386589
dc.description.abstractWith 40% of approved drugs and 90% of drugs in the pipeline being insoluble in water, developing methods to formulate and deliver hydrophobic drugs becomes urgent but remains a challenge. A large range of nanoparticles have been developed to encapsulate hydrophobic drugs. However, drug loading is usually less than 10% or even 1%. Herein, we report the fabrication of core‐shell nanoparticles having exceptionally high drug loading up to 65% (drug weight/the total weight of drug‐loaded nanoparticles) and high encapsulation efficiencies (>99%) based on modular biomolecule templating. Bifunctional amphiphilic peptides are designed to not only stabilize hydrophobic drug nanoparticles but also induce biosilicification at the nanodrug particle surface thus forming drug‐core silica‐shell nanocomposites. This platform technology is highly versatile for encapsulating various hydrophobic cargos. Furthermore, the high drug loading nanoparticles lead to better in vitro cytotoxic effects and in vivo suppression of tumor growth, highlighting the significance of using high drug loading nanoparticles.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofjournalAngewandte Chemie International Edition
dc.subject.fieldofresearchMacromolecular and Materials Chemistry
dc.subject.fieldofresearchBiomaterials
dc.subject.fieldofresearchNanobiotechnology
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchcode0303
dc.subject.fieldofresearchcode090301
dc.subject.fieldofresearchcode100703
dc.subject.fieldofresearchcode03
dc.titleBioinspired Core-Shell Nanoparticles for Hydrophobic Drug Delivery
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationYang, G; Liu, Y; Wang, H; Wilson, R; Hui, Y; Yu, A; Wibowo, D; Zhang, C; Whittaker, A; Middelberg, A; Zhao, C-X, Bioinspired Core-Shell Nanoparticles for Hydrophobic Drug Delivery, Angewandte Chemie International Edition
dc.date.updated2019-08-15T02:55:33Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Bioinspired Core-Shell Nanoparticles for Hydrophobic Drug Delivery, Angewandte Chemie, International Edition, which has been published in final form at 10.1002/anie.201908357. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
gro.hasfulltextFull Text
gro.griffith.authorWibowo, David


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