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  • Therapeutic Plasma Exchange in Renal Disorders

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    Ranganathan227041.pdf (633.5Kb)
    Author(s)
    Ranganathan, D
    John, GT
    Griffith University Author(s)
    Ranganathan, Dwarakanathan
    Year published
    2019
    Metadata
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    Abstract
    Nephrologists use hemodialysis and hemofiltration to remove low molecular weight toxic constituents, and increasingly deploy therapeutic plasma exchange (TPE)/plasmapheresis to eliminate higher molecular weight substances such as immunoglobulins or immune complexes from plasma. This review discusses different modalities of TPE, their application in renal disorders, its rationale and complications. TPE is recommended based on evidence, in alloantibody-mediated diseases such as humoral antibody mediated renal transplant rejection, autoantibody mediated glomerulonephritis (GN) disorders for example, anti-glomerular basement ...
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    Nephrologists use hemodialysis and hemofiltration to remove low molecular weight toxic constituents, and increasingly deploy therapeutic plasma exchange (TPE)/plasmapheresis to eliminate higher molecular weight substances such as immunoglobulins or immune complexes from plasma. This review discusses different modalities of TPE, their application in renal disorders, its rationale and complications. TPE is recommended based on evidence, in alloantibody-mediated diseases such as humoral antibody mediated renal transplant rejection, autoantibody mediated glomerulonephritis (GN) disorders for example, anti-glomerular basement membrane GN, as well as in antineutrophil cytoplasmic antibody mediated GN and antibody mediated thrombotic thrombocytopenic purpura. In many other renal illnesses, the rational use of TPE is gaining currency. Double membrane filtration, immune adsorption and cryofiltration are important modifications in TPE
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    Journal Title
    Indian Journal of Nephrology
    Volume
    29
    Issue
    3
    DOI
    https://doi.org/10.4103/ijn.IJN_420_17
    Copyright Statement
    © The Author(s) YEAR. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. If you alter, transform, or build upon this work, you may distribute the resulting work only under a licence identical to this one.
    Subject
    Clinical Sciences
    Medical and Health Sciences
    Science & Technology
    Life Sciences & Biomedicine
    Urology & Nephrology
    Plasmapheresis
    renal
    Publication URI
    http://hdl.handle.net/10072/386626
    Collection
    • Journal articles

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