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dc.contributor.authorFridman, Mikhail
dc.contributor.authorKrasko, Olga
dc.contributor.authorBranovan, Daniel Igor
dc.contributor.authorDabryian, Sviatlana
dc.contributor.authorPisarenko, Arthur
dc.contributor.authorLo, Chung Yau
dc.contributor.authorLam, Alfred King-Yin
dc.date.accessioned2019-08-19T00:14:09Z
dc.date.available2019-08-19T00:14:09Z
dc.date.issued2019
dc.identifier.issn0748-7983
dc.identifier.doi10.1016/j.ejso.2019.07.032
dc.identifier.urihttp://hdl.handle.net/10072/386628
dc.description.abstractBackground: The aim of the study is to analyse the factors related to permanent surgical complications in children and adolescents with papillary thyroid carcinoma treated by total thyroidectomy with central and bilateral neck dissections. Methods: Children and adolescents aged ≤18-year-old at presentation with papillary thyroid carcinoma during the years 1988–2010 underwent thyroid and lymph-node surgeries (with a median follow-up of 19.6 years) were analysed for post-surgical complications. Results: Permanent surgical morbidity occurred in 14% (n = 70) of patients who underwent total thyroidectomy as well as bilateral central and lateral neck dissections (n = 509). Factors associated with permanent complications included pN1 with extra-nodal extension, > 4 metastatic lymph nodes in the central neck compartment, presence of distant metastases and younger age of patients at surgery. Patients who received extensive surgery had better relapse-free survival rates (p < 0.001). Conclusion: Total thyroidectomy and bilateral central as well as lateral neck dissections for children and adolescents with papillary thyroid carcinoma was associated with substantial postoperative complications. Nevertheless, it is associated with better prognosis for young patients with thyroid cancer. Prophylactic compartment-oriented lymph node dissections to these patients could be the management protocol in experienced hands.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofjournalEuropean Journal of Surgical Oncology
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3211
dc.subject.keywordsChildhood
dc.subject.keywordsComplications
dc.subject.keywordsPapillary thyroid carcinoma
dc.subject.keywordsSurgical morbidity
dc.titleFactors affecting the approaches and complications of surgery in childhood papillary thyroid carcinomas
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationFridman, M; Krasko, O; Branovan, DI; Dabryian, S; Pisarenko, A; Lo, CY; Lam, AKY, Factors affecting the approaches and complications of surgery in childhood papillary thyroid carcinomas, European Journal of Surgical Oncology, 2019
dcterms.dateAccepted2019-07-31
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2019-08-18T22:57:11Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2019 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorLam, Alfred K.


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