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  • GPR68: An emerging drug target in cancer

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    Sriram247283.pdf (962.9Kb)
    Author(s)
    Wiley, SZ
    Sriram, K
    Salmerón, C
    Insel, PA
    Griffith University Author(s)
    Sriram, Krishna K.
    Year published
    2019
    Metadata
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    Abstract
    GPR68 (or ovarian cancer G protein-coupled receptor 1, OGR1) is a proton-sensing G-protein-coupled receptor (GPCR) that responds to extracellular acidity and regulates a variety of cellular functions. Acidosis is considered a defining hallmark of the tumor microenvironment (TME). GPR68 expression is highly upregulated in numerous types of cancer. Emerging evidence has revealed that GPR68 may play crucial roles in tumor biology, including tumorigenesis, tumor growth, and metastasis. This review summarizes current knowledge regarding GPR68—its expression, regulation, signaling pathways, physiological roles, and functions it ...
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    GPR68 (or ovarian cancer G protein-coupled receptor 1, OGR1) is a proton-sensing G-protein-coupled receptor (GPCR) that responds to extracellular acidity and regulates a variety of cellular functions. Acidosis is considered a defining hallmark of the tumor microenvironment (TME). GPR68 expression is highly upregulated in numerous types of cancer. Emerging evidence has revealed that GPR68 may play crucial roles in tumor biology, including tumorigenesis, tumor growth, and metastasis. This review summarizes current knowledge regarding GPR68—its expression, regulation, signaling pathways, physiological roles, and functions it regulates in human cancers (including prostate, colon and pancreatic cancer, melanoma, medulloblastoma, and myelodysplastic syndrome). The findings provide evidence for GPR68 as a potentially novel therapeutic target but in addition, we note challenges in developing drugs that target GPR68.
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    Journal Title
    International Journal of Molecular Sciences
    Volume
    20
    Issue
    3
    DOI
    https://doi.org/10.3390/ijms20030559
    Copyright Statement
    © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
    Subject
    Other Chemical Sciences
    Genetics
    Other Biological Sciences
    GPR68
    RNA-seq
    acidosis
    proton-sensing GPCRs
    tumor microenvironment
    Publication URI
    http://hdl.handle.net/10072/386673
    Collection
    • Journal articles

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