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dc.contributor.authorWiley, SZ
dc.contributor.authorSriram, K
dc.contributor.authorSalmerón, C
dc.contributor.authorInsel, PA
dc.date.accessioned2019-08-26T03:15:02Z
dc.date.available2019-08-26T03:15:02Z
dc.date.issued2019
dc.identifier.issn1661-6596
dc.identifier.doi10.3390/ijms20030559
dc.identifier.urihttp://hdl.handle.net/10072/386673
dc.description.abstractGPR68 (or ovarian cancer G protein-coupled receptor 1, OGR1) is a proton-sensing G-protein-coupled receptor (GPCR) that responds to extracellular acidity and regulates a variety of cellular functions. Acidosis is considered a defining hallmark of the tumor microenvironment (TME). GPR68 expression is highly upregulated in numerous types of cancer. Emerging evidence has revealed that GPR68 may play crucial roles in tumor biology, including tumorigenesis, tumor growth, and metastasis. This review summarizes current knowledge regarding GPR68—its expression, regulation, signaling pathways, physiological roles, and functions it regulates in human cancers (including prostate, colon and pancreatic cancer, melanoma, medulloblastoma, and myelodysplastic syndrome). The findings provide evidence for GPR68 as a potentially novel therapeutic target but in addition, we note challenges in developing drugs that target GPR68.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofpagefrom559
dc.relation.ispartofpageto559
dc.relation.ispartofissue3
dc.relation.ispartofjournalInternational Journal of Molecular Sciences
dc.relation.ispartofvolume20
dc.subject.fieldofresearchOther Chemical Sciences
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchOther Biological Sciences
dc.subject.fieldofresearchcode0399
dc.subject.fieldofresearchcode0604
dc.subject.fieldofresearchcode0699
dc.subject.keywordsGPR68
dc.subject.keywordsRNA-seq
dc.subject.keywordsacidosis
dc.subject.keywordsproton-sensing GPCRs
dc.subject.keywordstumor microenvironment
dc.titleGPR68: An emerging drug target in cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationWiley, SZ; Sriram, K; Salmerón, C; Insel, PA, GPR68: An emerging drug target in cancer, International Journal of Molecular Sciences, 2019, 20 (3), pp. 559-559
dcterms.dateAccepted2019-01-24
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2019-08-22T03:59:49Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
gro.hasfulltextFull Text
gro.griffith.authorSriram, Krishna K.


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