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  • Development of a nerve stretcher for in vivo stretching of nerve fibres

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    Sahar240498.pdf (649.4Kb)
    Author(s)
    Sahar, Muhammad Sana Ullah
    Mettyas, Tamer
    Barton, Matthew
    Griffith University Author(s)
    Mettyas, Tamer
    Sahar, m
    Barton, Matthew J.
    Year published
    2019
    Metadata
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    Abstract
    Axons in vitro respond to mechanical stimulus and can be stretched mechanically to increase their rate of growth. This type of accelerated growth under the influence of tensile forces alone appears independent of chemical cues and growth cones. The stretch-growth of axonal tracts ex vivo and their transient lengthening have been discussed in literature extensively; however; evidence of in vivo investigations is scarce. Stretching axons, although practical ex vivo, is more challenging in vivo due to the difficulties of applying in situ axial tensile forces. Here, a technique has been developed to apply axial tensile forces ...
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    Axons in vitro respond to mechanical stimulus and can be stretched mechanically to increase their rate of growth. This type of accelerated growth under the influence of tensile forces alone appears independent of chemical cues and growth cones. The stretch-growth of axonal tracts ex vivo and their transient lengthening have been discussed in literature extensively; however; evidence of in vivo investigations is scarce. Stretching axons, although practical ex vivo, is more challenging in vivo due to the difficulties of applying in situ axial tensile forces. Here, a technique has been developed to apply axial tensile forces to a peripheral nerve in vivo. A device has been constructed, called a Nerve Stretcher, which makes use of negative gauge pressure to pull sectioned nerve stumps in a confined nerve prosthesis. This article presents the development of this device and a discussion of the methodology used to hold sciatic nerve stumps in a T-shaped nerve prosthesis. The findings of this study will form the basis of future nerve-stretch growth studies.
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    Journal Title
    Biomedical Physics and Engineering Express
    Volume
    5
    Issue
    4
    DOI
    https://doi.org/10.1088/2057-1976/ab2ca7
    Copyright Statement
    © 2019 Institute of Physics Publishing. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher.Please refer to the journal's website for access to the definitive, published version.
    Subject
    Biomedical Engineering
    Medical Biotechnology
    Science & Technology
    Life Sciences & Biomedicine
    Radiology, Nuclear Medicine & Medical Imaging
    axonal stress
    Peripheral nerve
    Publication URI
    http://hdl.handle.net/10072/386714
    Collection
    • Journal articles

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