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dc.contributor.authorSahar, Muhammad Sana Ullah
dc.contributor.authorMettyas, Tamer
dc.contributor.authorBarton, Matthew
dc.date.accessioned2019-08-29T00:52:14Z
dc.date.available2019-08-29T00:52:14Z
dc.date.issued2019
dc.identifier.issn2057-1976
dc.identifier.doi10.1088/2057-1976/ab2ca7
dc.identifier.urihttp://hdl.handle.net/10072/386714
dc.description.abstractAxons in vitro respond to mechanical stimulus and can be stretched mechanically to increase their rate of growth. This type of accelerated growth under the influence of tensile forces alone appears independent of chemical cues and growth cones. The stretch-growth of axonal tracts ex vivo and their transient lengthening have been discussed in literature extensively; however; evidence of in vivo investigations is scarce. Stretching axons, although practical ex vivo, is more challenging in vivo due to the difficulties of applying in situ axial tensile forces. Here, a technique has been developed to apply axial tensile forces to a peripheral nerve in vivo. A device has been constructed, called a Nerve Stretcher, which makes use of negative gauge pressure to pull sectioned nerve stumps in a confined nerve prosthesis. This article presents the development of this device and a discussion of the methodology used to hold sciatic nerve stumps in a T-shaped nerve prosthesis. The findings of this study will form the basis of future nerve-stretch growth studies.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherIOP Publishing
dc.relation.ispartofissue4
dc.relation.ispartofjournalBiomedical Physics and Engineering Express
dc.relation.ispartofvolume5
dc.subject.fieldofresearchBiomedical Engineering
dc.subject.fieldofresearchMedical Biotechnology
dc.subject.fieldofresearchcode0903
dc.subject.fieldofresearchcode1004
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsRadiology, Nuclear Medicine & Medical Imaging
dc.subject.keywordsaxonal stress
dc.subject.keywordsPeripheral nerve
dc.titleDevelopment of a nerve stretcher for in vivo stretching of nerve fibres
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSahar, MSU; Mettyas, T; Barton, M, Development of a nerve stretcher for in vivo stretching of nerve fibres, Biomedical Physics and Engineering Express, 2019, 5 (4)
dc.date.updated2019-08-27T00:42:56Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2019 Institute of Physics Publishing. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher.Please refer to the journal's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorMettyas, Tamer
gro.griffith.authorSahar, m
gro.griffith.authorBarton, Matthew J.


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