Show simple item record

dc.contributor.authorHoang, Phuc Dang
dc.contributor.authorShabab, Tara
dc.contributor.authorShafiee, Abbas
dc.contributor.authorPeiffer, Quentin C
dc.contributor.authorFox, Kate
dc.contributor.authorNhiem, Tran
dc.contributor.authorDargaville, Tim R
dc.contributor.authorHutmacher, Dietmar W
dc.contributor.authorTran, Phong A
dc.date.accessioned2019-08-27T04:25:24Z
dc.date.available2019-08-27T04:25:24Z
dc.date.issued2019
dc.identifier.issn1758-5082
dc.identifier.doi10.1088/1758-5090/ab14ff
dc.identifier.urihttp://hdl.handle.net/10072/386730
dc.description.abstractTissue engineering macroporous scaffolds are important for regeneration of large volume defects resulting from diseases such as breast or bone cancers. Another important part of the treatment of these conditions is adjuvant drug therapy to prevent disease recurrence or surgical site infection. In this study, we developed a new type of macroporous scaffolds that have drug loading and release functionality to use in these scenarios. 3D printing allows for building macroporous scaffolds with deterministically designed complex architectures for tissue engineering yet they often have low surface areas thus limiting their drug loading capability. In this proof-of-concept study, we aimed to introduce microscale porosity into macroporous scaffolds to allow for efficient yet simple soak-loading of various clinical drugs and control their release. Manufacturing of scaffolds having both macroporosity and microscale porosity remains a difficult task. Here, we combined porogen leaching and 3D printing to achieve this goal. Porogen microparticles were mixed with medical grade polycaprolactone and extruded into scaffolds having macropores of 0.7 mm in size. After leaching, intra-strut microscale pores were realized with pore size of 20–70 μm and a total microscale porosity of nearly 40%. Doxorubicin (DOX), paclitaxel (PTX) and cefazolin (CEF) were chosen as model drugs of different charges and solubilities to soak-load the scaffolds and achieved loading efficiency of over 80%. The microscale porosity was found to significantly reduce the burst release allowing the microporous scaffolds to release drugs up to 200, 500 and 150 h for DOX, PTX and CEF, respectively. Finally, cell assays were used and confirmed the bioactivities and dose response of the drug-loaded scaffolds. Together, the findings from this proof-of-concept study demonstrate a new type of scaffolds with dual micro-, macro-porosity for tissue engineering applications with intrinsic capability for efficient loading and sustained release of drugs to prevent post-surgery complications.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherIOP Publishing
dc.relation.ispartofissue3
dc.relation.ispartofjournalBiofabrication
dc.relation.ispartofvolume11
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchMedical biotechnology
dc.subject.fieldofresearchcode4003
dc.subject.fieldofresearchcode3206
dc.subject.keywordsScience & Technology
dc.subject.keywordsTechnology
dc.subject.keywordsEngineering, Biomedical
dc.subject.keywordsMaterials Science, Biomaterials
dc.subject.keywordsEngineering
dc.title3D printed dual macro-, microscale porous network as a tissue engineering scaffold with drug delivering function
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationHoang, PD; Shabab, T; Shafiee, A; Peiffer, QC; Fox, K; Nhiem, T; Dargaville, TR; Hutmacher, DW; Tran, PA, 3D printed dual macro-, microscale porous network as a tissue engineering scaffold with drug delivering function, Biofabrication, 2019, 11 (3)
dc.date.updated2019-08-27T04:21:15Z
gro.hasfulltextNo Full Text
gro.griffith.authorHutmacher, Dietmar W.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record