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dc.contributor.authorKlyne, DM
dc.contributor.authorMoseley, GL
dc.contributor.authorSterling, M
dc.contributor.authorBarbe, MF
dc.contributor.authorHodges, PW
dc.date.accessioned2019-08-28T06:41:50Z
dc.date.available2019-08-28T06:41:50Z
dc.date.issued2019
dc.identifier.issn1526-5900
dc.identifier.doi10.1016/j.jpain.2019.03.001
dc.identifier.urihttp://hdl.handle.net/10072/386745
dc.description.abstractCentral sensitization is considered to have a pathophysiological role in chronic low back pain (LBP). Whether individuals with increased central sensitization early in their condition are more likely to develop persistent pain or whether it increases over time is unclear. This study aimed to determine whether sensory profiles during acute LBP differ between individuals who did and did not recover by 6 months and to identify subgroups associated with outcomes. Individuals with acute LBP (<2 weeks of onset; N = 99) underwent pain threshold (heat/cold/pressure) and conditioned pain modulation testing after completing questionnaires related to pain/disability, sleep, and psychological status. Sensory measures were compared during the acute phase (baseline) and longitudinally (baseline/6 months) between unrecovered (greater or unchanged pain and disability), partially recovered (improved but not recovered pain and/or disability), and recovered (no pain and disability) participants at 6 months. We assessed baseline patterns of sensory sensitivity alone, and with psychological and sleep data, using hierarchical clustering and related the clusters to outcome (pain/disability) at 3 and 6 months. No sensory measure at either time point differed between groups. Two subgroups were identified that associated with more (“high sensitivity”) or less (“high sensitivity and negative psychological state”) recovery. These data seem to suggest that central sensitization during the acute phase resolves for many patients, but is a precursor to the transition to chronicity when combined with other psychological features. Perspective: Central sensitization signs during early acute LBP does not necessarily precede poor outcome, but may be sustained in conjunction with other psychological factors and facilitate pain persistence.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom994
dc.relation.ispartofpageto1009
dc.relation.ispartofissue8
dc.relation.ispartofjournalThe Journal of Pain
dc.relation.ispartofvolume20
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchPsychology and Cognitive Sciences
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode17
dc.subject.keywordsCentral sensitization
dc.subject.keywordsconditioned pain modulation
dc.subject.keywordshyperalgesia
dc.subject.keywordsperipheral sensitization
dc.subject.keywordstransition to chronicity
dc.titleAre Signs of Central Sensitization in Acute Low Back Pain a Precursor to Poor Outcome?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKlyne, DM; Moseley, GL; Sterling, M; Barbe, MF; Hodges, PW, Are Signs of Central Sensitization in Acute Low Back Pain a Precursor to Poor Outcome?, The Journal of Pain, 2019, 20 (8), pp. 994-1009
dcterms.dateAccepted2019-03-02
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2019-08-28T06:37:56Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2019 American Pain Society. Published by Elsevier Ltd. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorSterling, Michele


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