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dc.contributor.authorGrimwood, Keith
dc.contributor.authorChang, Anne B
dc.description.abstractThe absence of licensed medications for non-cystic fibrosis bronchiectasis is concerning in the context of the high and increasing burden of bronchiectasis in adults 1 and children. 2 In The Lancet Respiratory Medicine , Charles Haworth and colleagues 3 report promising data from two double-blind randomised controlled trials (ORBIT-3 and ORBIT-4) examining the efficacy of a once-daily inhaled antibiotic composed of liposome-encapsulated ciprofloxacin and free ciprofloxacin (ARD-3150), which is a welcome advancement in the bronchiectasis field in which few such trials exist. 4 In ORBIT-3 and ORBIT-4, 3 Haworth and colleagues enrolled 278 (ORBIT-3) and 304 (ORBIT-4) patients with non-cystic fibrosis bronchiectasis who were chronically infected with Pseudomonas aeruginosa . Patients were randomly assigned (2:1) to receive either ARD-3150 or placebo, which was self-administered once daily for six 56-day treatment cycles, for 48 weeks. 3 The primary endpoint was time to the first pulmonary exacerbation from the date of randomisation to week 48. Treatment with ARD-3150 resulted in a significant prolongation of median time to first pulmonary exacerbation in ORBIT-4 of 230 days compared with 158 days in the placebo group, a difference of 72 days (hazard ratio 0·72 [95% CI 0·53–0·97], p=0·032), but no significant prolongation was observed in ORBIT-3 or a pooled analysis of both trials. Secondary and post-hoc analyses of pooled data revealed significant risk reductions in exacerbation frequency and severity in those receiving ARD-3150, and significant reductions in sputum P aeroginosa density during active treatment cycles, but no between-group changes in quality of life or lung function. 3
dc.relation.ispartofjournalLancet Respiratory Medicine
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchOther health sciences
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsCritical Care Medicine
dc.subject.keywordsRespiratory System
dc.subject.keywordsGeneral & Internal Medicine
dc.titleA new dawn: inhaled antibiotics for patients with bronchiectasis
dc.typeJournal article
dc.type.descriptionC2 - Articles (Other)
dcterms.bibliographicCitationGrimwood, K; Chang, AB, A new dawn: inhaled antibiotics for patients with bronchiectasis, Lancet Respiratory Medicine, 2019, 7 (3), pp. 188-189
gro.hasfulltextNo Full Text
gro.griffith.authorGrimwood, Keith

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