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dc.contributor.authorStuart, S
dc.contributor.authorLawson, RA
dc.contributor.authorYarnall, AJ
dc.contributor.authorNell, J
dc.contributor.authorAlcock, L
dc.contributor.authorDuncan, GW
dc.contributor.authorKhoo, TK
dc.contributor.authorBarker, RA
dc.contributor.authorRochester, L
dc.contributor.authorBurn, DJ
dc.date.accessioned2019-09-02T02:28:45Z
dc.date.available2019-09-02T02:28:45Z
dc.date.issued2019
dc.identifier.issn0885-3185
dc.identifier.doi10.1002/mds.27813
dc.identifier.urihttp://hdl.handle.net/10072/386841
dc.description.abstractBackground: Cumulative dementia incidence in Parkinson's disease (PD) is significant, with major personal and socioeconomic impacts on individuals with PD and their carers. Early identification of dementia risk is vital to ensuring optimal intervention. Saccadic deficits often distinguish neurodegenerative disorders and cognitive impairment, but their ability to predict cognitive decline in PD has yet to be determined. The aims of this study were to (1) evaluate baseline (6.4 ± 6.1 months since PD diagnosis) differences in pro‐saccadic metrics between those with early PD and healthy age‐matched adults; and (2) assess the ability of baseline pro‐saccades to predict subsequent cognitive decline over 4.5 years. Methods: One hundred and forty‐one PD and 90 age‐matched participants recruited at diagnosis underwent saccadometric assessment of pro‐saccades at baseline and had cognition assessed at baseline, 18, 36, and 54 months. Pro‐saccadic characteristics included latency, duration, amplitude, peak, and average velocity. Cognitive assessment included executive function, attention, fluctuating attention, and memory. Linear mixed‐effects models examined pro‐saccadic metrics as predictors of cognitive decline over 54 months. Results: Pro‐saccades were significantly impaired at baseline in PD compared with controls. Pro‐saccadic characteristics of latency, duration, peak, and average velocity predicted decline in global cognition, executive function, attention, and memory over 54 months in PD. In addition, only reduction in global cognition and attention were predicted by pro‐saccadic metrics in age‐matched adults, indicating that PD findings were not purely age related. Conclusions: Saccadic characteristics are impaired in early PD and are predictive of cognitive decline in several domains. Assessment of saccades may provide a useful non‐invasive biomarker for long‐term PD cognitive decline in early disease. © 2019 International Parkinson and Movement Disorder Society
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley Online
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto9
dc.relation.ispartofjournalMovement Disorders
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4207
dc.subject.fieldofresearchcode3209
dc.subject.keywordsParkinson's disease
dc.subject.keywordsbiomarker
dc.subject.keywordscognition
dc.subject.keywordsdementia
dc.subject.keywordssaccades
dc.titlePro-Saccades Predict Cognitive Decline in Parkinson's Disease: ICICLE-PD
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationStuart, S; Lawson, RA; Yarnall, AJ; Nell, J; Alcock, L; Duncan, GW; Khoo, TK; Barker, RA; Rochester, L; Burn, DJ, Pro-Saccades Predict Cognitive Decline in Parkinson's Disease: ICICLE-PD, Movement Disorders, 2019, pp. 1-9
dcterms.dateAccepted2019-07-12
dc.date.updated2019-09-02T01:56:11Z
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.hasfulltextNo Full Text
gro.griffith.authorKhoo, Tien Kheng


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