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dc.contributor.authorGuo, LC
dc.contributor.authorYu, S
dc.contributor.authorWu, D
dc.contributor.authorHuang, J
dc.contributor.authorLiu, T
dc.contributor.authorXiao, J
dc.contributor.authorHuang, W
dc.contributor.authorGao, Y
dc.contributor.authorLi, X
dc.contributor.authorZeng, W
dc.contributor.authorRutherford, S
dc.contributor.authorMa, W
dc.contributor.authorZhang, Y
dc.contributor.authorLin, L
dc.date.accessioned2019-09-02T03:48:25Z
dc.date.available2019-09-02T03:48:25Z
dc.date.issued2019
dc.identifier.issn0269-7491
dc.identifier.doi10.1016/j.envpol.2019.07.093
dc.identifier.urihttp://hdl.handle.net/10072/386851
dc.description.abstractPolychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and new flame retardants (NFRs) are known thyroid hormone (TH) disruptors, but their disrupting mechanisms in humans are not completely understood. In this study, we aimed to explore the disrupting mechanisms of the aforementioned chemicals via examining TH-regulated proteins and gene expression in human serum. Adult participants from an e-waste dismantling (exposed group) and a control region (control group) in South China provided blood samples for the research. Some compounds of PCBs, PBDEs, and NFRs showed strong binding affinity to the thyroid-stimulating hormone (TSH), thyroglobulin, thyroxine-binding globulin (TBG), gene expression of TH receptor α (TRα) and β, and iodothyronine deiodinase I (ID1). The highly exposed individuals had lower levels of TBG, TSH, and expression of TRα, but higher expression of ID1 than those of the control group. The disruption of TH-regulated proteins and gene expression suggested the exertion of different and, at times, even contradictory effects on TH disruption. However, no statistically significant difference was found in the TH levels between the exposed and the control group, implying that the TH disruption induced by these chemicals depends on the combined influence of multiple mechanisms. Gene expression appears to be an effective approach for investigations of TH disruption and the potential health effects.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom112925:1
dc.relation.ispartofpageto112925:9
dc.relation.ispartofissuePart B
dc.relation.ispartofjournalEnvironmental Pollution
dc.relation.ispartofvolume254
dc.subject.fieldofresearchAtmospheric sciences
dc.subject.fieldofresearchcode3701
dc.subject.keywordsGene expression
dc.subject.keywordsNew flame retardant
dc.subject.keywordsPolybrominated diphenyl ether
dc.subject.keywordsPolychlorinated biphenyl
dc.subject.keywordsThyroid hormone
dc.titleDisruption of thyroid hormone regulated proteins and gene expression by polychlorinated biphenyls, polybrominated diphenyl ethers and new flame retardants in residents of an e-waste region
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationGuo, LC; Yu, S; Wu, D; Huang, J; Liu, T; Xiao, J; Huang, W; Gao, Y; Li, X; Zeng, W; Rutherford, S; Ma, W; Zhang, Y; Lin, L, Disruption of thyroid hormone regulated proteins and gene expression by polychlorinated biphenyls, polybrominated diphenyl ethers and new flame retardants in residents of an e-waste region, Environmental Pollution, 2019, 254 (Part B), pp. 112925:1-112925:9
dcterms.dateAccepted2019-07-18
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2019-09-02T03:32:19Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2019 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorRutherford, Shannon


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